A family with oculoauriculovertebral dysplasia is reported in which there are nine affected members spanning three consecutive generations. It is concluded that despite the known genetic heterogeneity in this disorder, there is an autosomal dominant form. Thus, genetic counseling can only be given after proper completion of all the necessary clinical and family studies.
In patients with normal intraocular pressure (IOP), local ocular application of pilocarpine causes IOP elevation, reaching a maximum at 10–20 min, and a subsequent prolonged fall of IOP below the baseline. We have studied the effect of pilocarpine in normal subjects with low baseline IOP ( < 10 mm Hg). The initial rise was larger than in normotensive controls (21 vs. 12%) and the subsequent fall was of similar relative magnitude (20%) as that of normotensives. Lower baseline IOP values were associated with greater initial rises and smaller subsequent falls. The mechanisms that may explain the two phases of IOP response to the administration of pilocarpine are discussed.
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