Organophosphates (OP) and carbamates, frequently used pesticides, can cause a variety of adverse health effects, ranging from simple irritation of the skin and eyes to more severe effects. The aim of this study was to evaluate the association between chronic occupational pesticide exposure and changes in serum activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), alkaline phosphatase (ALP), acetylcholinesterase (AChE) and creatine phosphokinase (CPK) in orchard workers. In the study, 47 peach orchard workers were included, at the age from 19 to 60 years, with monthly exposure to pesticides from 5 to 20 days and 1 to 35 working years. The control group consisted of 40 healthy age-matched men, without exposure to pesticides. All orchard workers kept to safety precautions. 68% of workers reported some physical signs and symptoms. A significantly decreased AChE activity was detected in 10.6% of orchard workers and increased CPK activity in 40.4%. Very weak negative correlation was detected between AChE and ALP activities (r = -0.34, p = 0.001) and between AChE and CPK activities (r = -0.25, p = 0.02). No correlation was found between the serum AChE and day of monthly exposure, as well as years of exposure. The results have shown that orchard workers with decreased AChE activity and increased CPK activity should be monitored as workers with an increased risk for severe pesticide poisoning. These findings suggest that chronic occupational exposure to pesticides elicit mild toxic effects, as well as biochemical changes of unknown long-term consequences. Keywords: Toxic effects; Carbamates pesticide, Organophosphate pesticide, Serum enzymes, Orchard workers, Occupational exposure
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