No abstract

Cardiac amyloidosis, once considered untreatable, is now gaining well-deserved attention due to advances in imaging and the recent approval of targeted breakthrough therapies. In this paper, we discuss the role of radionuclide imaging in the evaluation and management of patients with the most common form of amyloidosis-cardiac transthyretin amyloidosis (ATTR). We provide a comprehensive summary of the literature interspersed with our institutional experience as appropriate, to deliver our perspective.

We have demonstrated that small organic molecules 1 and 2 catalyzed the direct aldol reaction of both acyclic and cyclic ketones with different aldehydes in an excess of water/brine. Excellent enantioselectivities up to >99% and diastereoselectivities up to 99% with very good yields were obtained by using much lower catalyst loadings (0.5 mol %).

We have demonstrated that a new class of l-proline-based organic compounds catalyzed the direct aldol reaction between aldehydes and acetone to provide beta-hydroxy ketones in good yields. The reaction is efficient, and 5-10 mol % of the catalyst and excellent enantioselectivities (97-99% ee) were obtained in both aromatic and aliphatic aldehydes. The presence of a gem-diphenyl group at the beta-carbon is necessary for high enantioselectivity.

Organocatalysts have emerged as a third major way of catalyzing a wide variety of reactions, besides metal catalysts and biocatalysts. They have gained tremendous importance because of their green chemistry perspective. The criteria for green chemistry would be largely fulfilled if the major component of the reaction mixture, i.e. the solvent, is water which is a suitable solvent in various biosynthetic reactions. In this feature article we have described reactions promoted by organocatalysts in a large excess of water, without any organic solvent or excess of any reactant. We have also explained the structural features required for organocatalysts to work well in aqueous media.