Aggregation-induced emission (AIE) properties of an easy-to-prepare and structurally planar Schiff base derivative of vitamin B6 cofactor pyridoxal (L) was investigated in DMSO-H2O mixed solvents. Compound L showed a weak...
In this study, a tetradentate Schiff base ligand L was synthesized by condensing o-phenylenediamine with two moles of pyridoxal. The solution of L in EtOH/DMSO showed aggregation-induced emission (AIE) behaviour...
Pyridoxal 5′-phosphate (PLP),
a biologically important coenzyme,
participates in several enzymatic reactions, and its marginal deficiency
in the human body can cause cardiovascular disease. However, the excess
accumulation of the non-essential Al3+ metal ion in the
human body can also cause serious health problems. Therefore, there
is significant interest in the detection and monitoring of both PLP
and Al3+. This paper introduced a red-emitting dual-ligand
co-functionalized copper nanoclusters β-CD-GSH-CuNCs for the
simultaneous detection of PLP and Al3+. The capped β-cyclodextrin
(β-CD) in β-CD-GSH-CuNCs selectively recognizes PLP by
forming a host–guest inclusion complex that caused fluorescence
quenching at 625 nm with the formation of an emission band at 488
nm. The ratiometric fluorescence from β-CD-GSH-CuNCs allowed
to detect PLP down to 5.29 μM. Further, the in situ-generated nano-assembly β-CD-GSH-CuNCs@PLP showed a selective
turn-on fluorescent response for Al3+. The complexation-induced
aggregation of nano-assembly resulted in strong fluorescence enhancement
at 451 nm that allowed to detect Al3+ down to 0.187 μM.
The analytical utility of β-CD-GSH-CuNCs@PLP was validated as
a nanoprobe by monitoring Al3+ concentrations in real environmental
water samples.
Contamination of hydrazine has severe effects on the environment and security systems due to its potent toxic and explosive nature. Therefore, the concept of nano and supramolecular chemistry was applied to develop a nanoassembly for the fluorescent turn-on detection of hydrazine. Weakly emissive silver nanoparticles (AgNPs) decorated with beta-cyclodextrin (β-CD) of size ∼7 nm (β-CD-AgNPs) was synthesized, characterized, and interacted with pyridoxal 5′-phosphate (PLP). With the addition of vitamin B 6 cofactor PLP into the β-CD-AgNPs solution resulted an instantaneous fluorescence enhancement at 532 nm due to the inclusion complexation occurred between the PLP and the β-CD decorated over AgNPs. The formation of inclusion complex between PLP and β-CD was investigated additionally by various theoretical and experimental methods. The nanoassembly PLP_β-CD-AgNPs upon interaction with hydrazine showed a selective turn-on fluorescence at 515 nm. The aldehyde group of PLP acts as the recognition unit and formed a Schiff base upon interaction with hydrazine. This nanoassembly can detect the concentration of hydrazine down to 0.513 μM, and applied successfully to quantify hydrazine from the real environmental samples.
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