Lower limb venous flow parameters differ significantly between healthy obese and nonobese individuals. These findings support the mechanical role of abdominal adipose tissue potentially leading to elevated risk for both venous thromboembolism and chronic venous insufficiency.

Purpose: To report the midterm outcome after stent-assisted angioplasty of occlusive disease at the common femoral artery bifurcation. Methods: Between 1995 and 2002, 27 consecutive patients (18 men; mean age 70 years, range 47–90) underwent angioplasty with stent implantation in 33 limbs; target sites included 19 common femoral arteries, the origins of 2 superficial or 4 profunda femoris arteries, and 8 bypass anastomoses. Results: Technical success was 100%. Patients were followed for a mean 30 months (95% CI 21 to 39), at which time the cumulative primary patency was 86% (95% CI 85% to 88%). At 3 years, 83% of the arteries were patent. Five restenoses were due to neointimal hyperplasia in 4 cases (3 bypass grafts) and strut failure of the only balloon-expandable stent used in this series. Restenoses due to neointimal hyperplasia at bypass anastomoses (3/8) were more common than in native arteries (2/25) (p=0.078); cumulative primary patency for the bypass subgroup was 71% (95% CI 59% to 82%) at a mean 23-month follow-up; 75% and 60% of the anastomoses were patent after 1 and 2 years, respectively. Conclusions: Angioplasty of obstructions in the common femoral artery and its bifurcation with implantation of self-expanding stents shows good midterm primary patency. Native artery lesions have a better outcome than stenoses at bypass anastomoses. The procedure does not preclude further endovascular interventions at the puncture site.

Increased arterial stiffness results from reduced elasticity of the arterial wall and is an independent predictor for cardiovascular risk. The gold standard for assessment of arterial stiffness is the carotid-femoral pulse wave velocity. Other parameters such as central aortic pulse pressure and aortic augmentation index are indirect, surrogate markers of arterial stiffness, but provide additional information on the characteristics of wave reflection. Peripheral arterial disease (PAD) is characterised by its association with systolic hypertension, increased arterial stiffness, disturbed wave reflexion and prognosis depending on ankle-brachial pressure index. This review summarises the physiology of pulse wave propagation and reflection and its changes due to aging and atherosclerosis. We discuss different non-invasive assessment techniques and highlight the importance of the understanding of arterial pulse wave analysis for each vascular specialist and primary care physician alike in the context of PAD.

Peripheral arterial disease (PAD) is associated with increased cardiovascular mortality that correlates with peripheral perfusion impairment as assessed by the anklebrachial arterial pressure index (ABI). Furthermore, PAD is associated with arterial stiffness and elevated aortic augmentation index (AIx). The purpose of this study was to investigate whether ABI impairment correlates with AIx and subendocardial viability ratio (SEVR), a measure of cardiac perfusion during diastole. AIx and SEVR were assessed by radial applanation tonometry in 65 patients with stable PAD (Rutherford stage I-III) at a tertiary referral center. AIx corrected for heart rate and SEVR were tested in a multivariate linear and logistic regression model to determine the association with ABI. Mean ABI was 0.8AE0.2, AIx 31%AE7%, and SEVR 141%AE26%. Multiple linear regression with AIx as a dependent variable revealed that AIx was significantly negatively associated with ABI (b=)11.5; 95% confidence interval [CI], )18.6 to )4.5; P=.002). Other variables that were associated with AIx were diastolic blood pressure (b=0.2; 95% CI, 0.1-0.4; P<.001), height (b=)46.2; 95% CI, )62.9 to )29.4; P<.001), body mass index (b=)0.4; 95% CI, )0.8 to )0.1; P=.023), and smoking (b=3.6; 95% CI, 0.6-6.6; P=.019). Multiple regression with SEVR as a dependent variable showed a significant correlation with ABI (b=33.2; 95% CI, 2.3-64.1; P=.036). Severity of lower limb perfusion impairment is related to central aortic pressure augmentation and to subendocardial viability ratio. This may be a potential pathophysiologic link that impacts cardiac prognosis in patients with PAD.