Over the last decade, polymer micelles and nanoparticles attracted an increasing interest in drug research because they can be used as efficient drug delivery systems 1 . Nanoparticles are submicron-sized polymeric colloidal particles with a therapeutic agent of interest encapsulated within their polymeric matrix 2 . The addition of an amphiphilic block copolymer made up of poly(ethylene oxide) and an aliphatic polyester, such as poly(ε-caprolactone) (PCL) or polylactide (PLA), to the formulation permits to take advantage of the protein repellent properties of PEO to increase the time live of the nanoparticles in the vascular residence.The use of polymeric nanoparticles for the delivery of complex antigens, the combination of antigens, and genetic vaccines makes them one of the most promising strategies for oral vaccination 3 . Polymeric carriers protect antigens against degradation and inactivation in the harsh gastro-intestinal environment and have the ability to enhance their transmucosal transport. When these copolymers have a targeting agent, the biodistribution of polymeric micelles can be modulated and can induce specific cellular uptake by receptor-mediated endocytosis.
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