The use of bupropion (BUP) involves a higher seizure risk than the use of other antidepressants, limiting its dose and widespread use. The two reported cases document anticonvulsant-BUP drug interactions through plasma levels. Carbamazepine appeared to decrease the plasma BUP to nondetectable levels, while hydroxybupropion was found at very high levels. Data presented suggest that BUP may increase sodium valproate levels. Conclusions from these case reports are tentative, pending further study. Monitering of BUP and its metabolites may ultimately prove useful in guiding clinicians dosing decisions, especially when mood stabilizers are combined with other psychotropic drugs in refractory bipolar patients.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.