Background:Polycystic ovary syndrome (PCOS) is a common endocrine problem, which is now recognized as not only a reproductive but also a metabolic disorder with long-term effects on women's health, it has a prevalence of 5–10% in India. Among PCOS, it has been reported to have a higher incidence of cardiovascular disorders. Epidemiological studies have demonstrated an association between an increase in the carotid intimo-medial wall thickness (CIMT) and cardiovascular dysfunction. The objective of this study was to compare the CIMT of PCOS with normal women.Materials and Methods:The cross-sectional case-control study was conducted in a tertiary care Hospital in South India. Fifty-four subjects with polycystic ovarian disease and 54 healthy women were enrolled into the study. PCOS was diagnosed by Rotterdam criteria, 2003. Both groups of women were investigated with CIMT and cardiovascular dysfunction.Results:The mean age of women with PCOS and controls were 24.4 ± 5.3 and 27.7 ± 6.0, respectively, whereas body mass index was significantly higher in PCOS than controls group. Mean carotid IMT was significantly higher in PCOS subjects (0.51 ± 0.078) than control subjects (0.44 ± 0.06).Conclusion:Higher CIMT values were observed in PCOS group compared to control group indicating the importance for measuring CIMT in women with PCOS to predict the risk of cardiovascular dysfunction (CVD).

We report the case of a 29-year-old male who presented to us with hematuria, dysuria and bilateral flank pain. On evaluation, the patient was found to have primary pleomorphic undifferentiated sarcoma of bladder with calcified pulmonary metastasis, confirmed with computerized tomography scan and immunohistochemistry.

Introduction Primary central nervous system (CNS) involvement of Hodgkin's lymphoma is very uncommon. There are only a few previous reports of Hodgkin's lymphoma of nodular lymphocyte predominant histology involving the CNS concurrently with systemic disease. Case presentation A 12-year-old boy with a history of painless left inguinal swelling and acute diplopia. There was an intensely enhancing lesion in the right midbrain on magnetic resonance imaging. The patient was diagnosed with stage IV Hodgkin's lymphoma of nodular lymphocyte predominance type by routine microscopy and immunohistochemistry of left inguinal lymph node biopsy with computed tomography-assisted staging. It was planned to treat him with six cycles of chemotherapy with intrathecal methotrexate, followed by radiotherapy to the CNS lesions. After two cycles of chemotherapy, the patient entered complete remission of all lesions including the CNS lesion documented by the positron emission tomography scan. Conclusion We are describing the course of this rare presentation of Hodgkin's lymphoma of nodular lymphocyte predominant histology involving the CNS and clinical challenge in its diagnosis and management of this case.

Background: Estimation of adiponectin levels in diabetic and non-diabetic fatty liver and healthy controls. Methods: We studied 25 subjects for diabetic fatty liver, 25 subjects for non-diabetic fatty liver and 25 healthy controls. Clinical evaluation included anthropometric measurements, BMI, biochemical investigations and adiponectin estimation by ELISA. Results: There were 15 males (60%) and 10 (40%)females subjects in the DFL group, 18 males (72%) and 7 females (28%) subjects in the NDFL group and 13 males (52%) and 12 females (48%) subjects in the control group. 80% (20) of the DFL patients and 72% (18) subjects of NDFL group had BMI >25kg/m 2. 80% (12 males and 8 females) of subjects in the DFL group and 68% (12 males and 5 females) had a waist circumference that indicated central obesity as per Indian cutoffs (>90 cm for females and >80 cm for males). The mean adiponectin (μg/ml) ± SD levels in DFL were 4.03 ± 0.43, NDFL was 5.01 ± 0.55 and in controls was 7.63 ± 0.66, the difference being statistically significant with P <0.001. The difference in the adiponectin levels was statistically significant between each of the three groups with P <0.001. There was no difference in serum adiponectin levels between males and females in all three groups. Conclusion: The chief conclusion of this study are that serum adiponectin levels are lower in subjects with NAFLD than those without it; adiponectin levels are inversely related to the degree of steatosis in NAFLD, with the lowest levels in more severe forms of steatosis.

Background: Obesity is at a rising trend among the childhood age group and is a WHO priority on classification of non-communicable diseases. High income group countries once had a statistically higher percent of obesity problems which has been extended both to the developing and low- income countries. Prevalence rate of obesity in India vary between 11.8% to 31.3% and is higher among the women than men. Obesity also affects the physical and cardio-respiratory fitness thereby leading to a group of metabolic, cardiovascular and musculoskeletal disorders. An association between BMI, musculo-skeletal and cardio-respiratory fitness is less reported among the young adult girl population in the context of Indian professional students. Aim & Objectives: To assess few of the musculo-skeletal, cardio-respiratory parameters in relation to BMI among the young adult girl students of medical and dental colleges. Material & Methods: One hundred and seventy-one girl students in the range of 19 to 21 years were randomly selected from the educational institute of Sullia, Dakshina Kannada, Karnataka and were assessed for BMI, muscular strength, handgrip strength, flexibility test, cardio-respiratory test and pulmonary function test by standard methods. Data was analysed. Results: Musculo-skeletal flexibility, strength, cardiorespiratory fitness and pulmonary functions have an inverse association when compared to the BMI and weight of the girl students. Conclusion: Obesity and overweight reduces the flexibility, musculoskeletal and cardio-respiratory fitness in addition to the pulmonary functions among the young adult girl population as confirmed by the battery of tests. Bangladesh Journal of Medical Science Vol.20(2) 2021 p.384-389