Currently, the development of pharmaceutical science and industry, the introduction and development of evidence-based medicine dictate the need for a voluminous and at the same time careful attitude to the standardization of newly proposed original dosage forms. But any modern instrument variants require the use of a SS – standard capable of confirming the stability and expediency of the developed methodology. Therefore, this article focuses not only on technology and the choice of the optimal composition, but also on analytical support.
In this paper, we have studied the possibility of obtaining a rectal dosage form of lornoxicam based on microemulsion by selecting the optimal composition that provides the necessary release of the active substance, as well as solving the issue of standardization of the dosage form using a standard sample.
The article presents the studies on the development of a method for the quantitative determination of lornoxime in suppositories using UV spectrophotometry. The optical densities of the test solutions were recorded at a wavelength of 375 nm. The absorption spectra of standard solutions of lornoxicam, as well as of tested solutions of suppositories were obtained. The relative standard deviation was 2.31%.
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