Objective: Proton pencil-beam scanning arcs (PBS arcs) have gained much attention during the past years, due to its potential for increased clinical benefit compared to conventional proton therapy. Previous studies on PBS arcs have primarily been focused on plan quality, and lately efforts have been made to reduce the delivery time. However, the methods presented so far suffer from slow optimization processes. Approach: We present a new method for fast robust optimization of PBS arc plans. The new method assigns a single energy layer per discretized direction prior to spot weight optimization and reduces the number of initial spots considerably compared to conventional methods. We used the new method for three prostate cancer patients with a prescribed dose to the CTV of 77 GyRBE in 35 fractions. For each of the patients, four plans were created: 2-beam IMPT (2IMPT), 1-beam PBS arc (1Arc), 1-beam PBS arc without focus on reducing upward energy jumps (1Arc_unseq) and two-beam PBS arc (2Arc). Main results: All PBS arc plans show a reduced integral dose compared to their respective 2IMPT plans. In the nominal case, the average CTV D98 and D2 metrics over the three patients were best for the 2Arc, followed by 2IMPT (D98/D2: 7523/7986 cGyRBE (2IMPT), 7478/7984 cGy (1Arc), 7486/7951 cGy (1Arc_unseq), 7531/7951 cGyRBE (2Arc)). The average robust target coverage in terms of V95 of the voxelwise minimum dose distribution (evaluated over 42 scenarios) was: 98.0% (2IMPT), 88.6% (1Arc), 92.5% (1Arc_unseq), 97.3% (2Arc). The optimization time, including spot selection and spot dose computation, is longest for the 2Arc plan, but is below 6 minutes for all patients. The maximum estimated delivery time for all types of arc plans is just above 5 minutes. Significance: The ability for efficient treatment planning constitutes an important step towards clinical introduction of proton PBS arcs.
BackgroundProton arcs have shown potential to reduce the dose to organs at risks (OARs) by delivering the protons from many different directions. While most previous studies have been focused on dynamic arcs (delivery during rotation), an alternative approach is discrete arcs, where step‐and‐shoot delivery is used over a large number of beam directions. The major advantage of discrete arcs is that they can be delivered at existing proton facilities. However, this advantage comes at the expense of longer treatment times.PurposeTo exploit the dosimetric advantages of proton arcs, while achieving reasonable delivery times, we propose a partitioning approach where discrete arc plans are split into subplans to be delivered over different fractions in the treatment course.MethodsFor three oropharyngeal cancer patients, four different arc plans have been created and compared to the corresponding clinical IMPT plan. The treatment plans are all planned to be delivered in 35 fractions, but with different delivery approaches over the fractions. The first arc plan (1×30) has 30 directions to be delivered every fraction, while the others are partitioned into subplans with 10 and 6 beam directions, each to be delivered every third (3×10), fifth fraction (5×6), or seventh fraction (7×10). All plans are assessed with respect to delivery time, target robustness over the treatment course, doses to OARs and NTCP for dysphagia and xerostomia.ResultsThe delivery time (including an additional delay of 30 s between the discrete directions to simulate manual interaction with the treatment control system) is reduced from on average 25.2 min for the 1×30 plan to 9.2 min for the 3×10 and 7×10 plans and 5.7 min for the 5×6 plans. The delivery time for the IMPT plan is 7.9 min. When accounting for the combination of delivery time, target robustness, OAR sparing, and NTCP reduction, the plans with 10 directions in each fraction are the preferred choice. Both the 3×10 and 7×10 plans show improved target robustness compared to the 1×30 plans, while keeping OAR doses and NTCP values at almost as low levels as for the 1×30 plans. For all patients the NTCP values for dysphagia are lower for the partitioned plans with 10 directions compared to the IMPT plans. NTCP reduction for xerostomia compared to IMPT is seen in two of the three patients. The best results are seen for the first patient, where the NTCP reductions for the 7×10 plan are 1.6 p.p. (grade 2 xerostomia) and 1.5 p.p. (grade 2 dysphagia). The corresponding NTCP reductions for the 1×30 plan are 2.7 p.p. (xerostomia, grade 2) and 2.0 p.p. (dysphagia, grade 2).ConclusionsDiscrete proton arcs can be implemented at any proton facility with reasonable treatment times using a partitioning approach. The technique also makes the proton arc treatments more robust to changes in the patient anatomy.
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