Background:
Hemoglobin is an essential biomolecule for the transportation of oxygen,
therefore, its assessment is also important to be done frequently in numerous clinical practices. Traditional
invasive techniques have concomitant shortcomings, such as time delay, the onset of infections,
and discomfort, which necessitate a non-invasive hemoglobin estimation solution to get rid
of these constraints in health informatics. Currently, various techniques are underway in the allied
domain, and scanty products are also feasible in the market. However, due to the low satisfaction
rate, invasive solutions are still assumed as the gold standard. Recently introduced technologies effectively
evolved as optical spectroscopy and digital photographic concepts on different sensing
spots, e.g., fingertip, palpebral conjunctiva, bulbar conjunctiva, and fingernail. Productive sensors
develop more than eight wavelengths to compute hemoglobin concentration and four wavelengths
to display only Hb-index (trending of hemoglobin) either in disposable adhesive or reusable cliptype
sensor’s configuration.
Objective:
This study aims at an optimistic optical spectroscopic technique to measure hemoglobin
concentration and conditional usability of non-invasive blood parameters’ diagnostics at point-ofcare.
Methods:
Two distinguishable light emitting sources (810 nm and 1300 nm) are utilized at isosbestic
points with a single photodetector (800-1700 nm). With this purpose, reusable finger probe assembly
is facilitated in transmittance mode based on the newly offered sliding mechanism to block
ambient light.
Results:
Investigation with proposed design presents correlation coefficients between reference hemoglobin
and every individual feature, a multivariate linear regression model for highly correlated
independent features. Moreover, principal component analytical model with multivariate linear regression
offers mean bias of 0.036 and -0.316 g/dL, precision of 0.878 and 0.838 and limits of
agreement from -1.685 to 1.758 g/dL and -1.790 to 1.474 g/dL for 18 and 21 principal components,
respectively.
Conclusion:
The encouraging readouts emphasize favorable precision; therefore, it is proposed
that the sensing system is amenable to assess hemoglobin in settings with limited resources and
strengthening future routes for the point of care applications.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.