A recyclable, inexpensive, non-toxic and environmentally benign catalytic system comprised of magnetically separable copper ferrite (CuFe 2 O 4 ) nanoparticles has been developed for the synthesis of diaryl, alkyl/aryl sulfones. Arylsulfinic acid salts are coupled with various alkyl/aryl halides/boronic acids to afford the corresponding diaryl, alkyl/aryl sulfones in good to excellent yields under the identical catalytic system. A wide range of functional group tolerance, with facile recovery of the catalyst by application of an external magnetic field, and consistently high catalytic efficiency for five consecutive cycles render the protocol operationally attractive.
A practical method to synthesize substituted b-keto sulfones directly from ketones at room temperature has been developed. This method involves the nucleophilic addition of a base generated enolate to sulfonyl iodide. The reaction shows high chemoselectivity for the addition of a sulfonyl group to an a-carbon over a hydroxyl group. In addition, the given protocol provides good to excellent yields of b-keto sulfones under mild reaction conditions. Moreover, the regiochemical aspect of the protocol is also explored.
An iron-catalyzed syn-diacetoxylation of alkenes and 1,2-oxyacetoxylation of terminala lkynes has been developed using (diacetoxyiodo)benzenea s oxidant. Ab road range of internal and terminal alkenes, including electron-rich as wella se lectron-deficient alkenes,g avet he desired products in good to excellent yields with high diastereoselectivity (up to > 99:1 dr). In addition the high catalytic activity of iron catalysisfor the 1,2-oxyacetoxylation of terminal alkynes is also reported. Ther oles of catalyst, oxidant and other reactionp arameters were evaluated for activation of the unsaturated bond.
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