We prospectively evaluated the safety and efficacy of total gut irrigation (TGI) using normal saline with added potassium (NS) and polyethylene glycol (PG) in patients undergoing a variety of colorectal procedures including single-stage pull-through for Hirschsprung's disease (HD). Fifty-four patients were randomly assigned into one of the two groups (NS or PG). Pre- and post-TGI weight, abdominal girth, and serum electrolytes were assessed. Patients were also evaluated for vomiting and abdominal discomfort. At surgery, bowel preparation was evaluated, and postoperative complications were recorded. Both NS and PG are safe and effective agents for TGI. No patient in either group had any clinical or statistically significant change in the evaluated parameters. The amount of NS required for TGI was significantly higher than PG, and PG was better tolerated than NS. All patients with HD completed TGI, although one patient with long segment HD had abdominal distension.

New York City taxi rides form the core of the traffic in the city of New York. The many rides taken every day by New Yorkers in the busy city can give us a great idea of traffic times, road blockages, and so on. Predicting the duration of a taxi trip is very important since a user would always like to know precisely how much time it would require of him to travel from one place to another. Given the rising popularity of app-based taxi usage through common vendors like Ola and Uber, competitive pricing has to be offered to ensure users choose them. Prediction of duration and price of trips can help users to plan their trips properly, thus keeping potential margins for traffic congestions. It can also help drivers to determine the correct route which in-turn will take lesser time as accordingly. Moreover, the transparency about pricing and trip duration will help to attract users at times when popular taxi app-based vendor services apply surge fares. Thus in this research study, we used real-time data which customers would provide at the start of a ride, or while booking a ride to predict the duration and fare. This data includes pickup and drop-off point coordinates, the distance of the trip, start time, number of passengers, and a rate code belonging to the different classes of cabs available such that the rate applied is based on a regular or airport basis. Hereafter, we applied XGBoost and Multi-Layer Perceptron models to find out which one of them provides better accuracy and relationships between real-time variables. At last, a comparison of the two mentioned algorithms facilitates us to decide that XGBoost is more fitter and efficient than Multi-Layer Perceptron for taxi trip duration-based predictions.

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Silymarin, a polyphenolic flavonoid isolated from milk thistle (Silybum marianum), is being used clinically in Europe and Asia for the treatment of liver diseases. Silymarin has a strong antioxidative action capable of scavenging both free radicals and reactive oxygen species responsible for cancer. Silymarin, a powerful hepatoprotective and antioxidant, was chosen in the present study and was tested for its antimutagenic activity using an in vitro test, the Ames bacterial reverse mutation assay. The results indicated that silymarin showed a significant mutagenicity in frame shift mutant strains (TA97a and TA98) with metabolic activation. This compound also showed stronger antimutagenic effect against 2-aminofluorene and 4-nitroquinoline N-oxide induced mutation. When pre-, co- and post-treatment of silymarin was carried out, it showed stronger antimutagenic activity in the post-treatment with 2-aminofluorene and 4-nitroquinoline N-oxide in TA97a and TA98 strains.

In the title compound, C21H27NO5, the dihydropyridine ring adopts a boat conformation. The ethoxy­phenyl ring is oriented approximately perpendicular to the planar part of the dihydropyridine ring, making a dihedral angle of 89.45 (6)°. An intra­molecular C—H⋯O hydrogen bond generates an S(6) ring motif. In the crystal structure, neighbouring mol­ecules are linked into chains along the a axis by N—H⋯O hydrogen bonds and the chains are inter­connected into two-dimensional networks parallel to the ab plane by C—H⋯O hydrogen bonds. The structure is further stabilized by weak C—H⋯π inter­actions.

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