An efficient synthetic method was developed for the preparation of 1-octacosanol (C 28 -alcohol) from commercially available lipid-based intermediates namely sebacic acid (decanedioic acid) and stearyl alcohol. The key step in the synthesis is the preparation of tert-butyl dimethyl octacos-10-enyloxy silane from 10-tert-butyl dimethyl silanyloxy decanal and octadecyl triphenylphosphonium bromide salt employing Witting reaction. This product on simultaneous hydrogenation of double bond and deprotection of tert-butyldimethylsilyl protecting group in a single step on treatment with Pd/C and H 2 in methanol at ambient temperature resulted octacosanol in 95% yields. The products were characterised by IR, 1 H NMR, and GC-MS analysis.