The present study investigates the anti-inflammatory activity of methanolic and chloroform extracts of Tragia cannabina. The whole plant of Tragia cannabina was extracted with methanol and chloroform by using soxhlet apparatus. The effect of both extracts of Tragia cannabina was studied on carrageenan induced paw edema. The methanolic extract decreased the edema induced in hind paw. The percentage inhibition of paw edema was maximum with methanolic and chloroform extracts of Tragia cannabina at 300mg/kg body weight and has showed significant anti-inflammatory activity. It has been concluded that both the methanolic and chloroform extracts of Tragia cannabina showed significant anti-inflammatory activity comparable to that of reference standard Ibuprofen.DOI: http://dx.doi.org/10.3329/icpj.v1i8.11253 International Current Pharmaceutical Journal 2012, 1(8): 213-216
Background: Tea tree oil, also known as Melaleuca alternifolia essential oil is widely used in skin care cosmeceuticals for its antibacterial, antifungal, analgesic and anti-inflammatory effect. The complex and variable composition of the oil poses many challenges to the analytical chemist and a recent survey of analytical methods indicated only a few simple and validated methods for estimation of the oil. Aim: A quality by design approach has therefore been adopted to develop a simple and novel UV spectrophotometric method for estimation of tea tree oil in bulk and cosmeceutical creams. Materials and Methods: UV spectrophotometric method was developed for estimation of Tea tree oil using dichloromethane-methanol (54 % v/v) solvent system. The method was then validated under optimized conditions for accuracy, precision and ruggedness, limit of detection and limit of quantification as per ICH: Q2 (R 1) guidelines. Results: A characteristic spectral peak was observed at 267 nm and linearity was established over a concentration range of 10-160 mcg/ml with R 2 value of 0.9961. Accuracy based on recovery studies, 100.5-113.6 %, precision and ruggedness based on % RSD values less than 2 %, LOD, 0.1277mcg/ml and LOQ and 4.195 mcg/ml indicated that the method is sensitive enough to be used for routine estimation. Conclusion: The method is robust and has been used to determine the essential oil content of two cosmeceutical creams.
Nizatidine is an anti-secretogogue and a gastroprotective drug with a half-life of 1-2 h and is well absorbed in the stomach. This study aimed to optimize the process and develop floating microparticles of nizatidine that are based on low methoxyl pectin. Oil-in-oil dispersion method and Taguchi orthogonal array design were employed, and the prolonged residence time of the microparticles in the stomach was demonstrated. The constraints for independent variables, viz. A-polymer, B-internal solvent volume, C-surfactant, D-stirring rate and E-stirring time were set to generate the experimental runs. Particle size, percentage yield, micromeritic properties, entrapment efficiency, in vitro buoyancy and in vitro release were characterized. Surface morphology, zeta potential, in vitro release kinetics and in vivo floating performance of the optimized formulation was examined. The microparticles were free-flowing, irregular in shape and had a mean particle size distribution of 73-187 μ. Low methoxyl pectin played a predominant role in achieving buoyancy and optimum gastric retention for the modified release of the drug, suggesting Korsmeyer-Peppas model as the possible release mechanism. In vivo radiographic study in rabbits revealed that the drug was retained in the stomach for a period of 6 h. These results indicate that nizatidine floating microparticulate system provides modified drug release for the effective treatment of gastric ulcer.
<p>The present study investigates the anti-inflammatory activity of methanolic and chloroform extracts of<strong><em> </em></strong><em>Tragia cannabina</em>. The whole plant of <em>Tragia cannabina</em> was extracted with methanol and chloroform by using soxhlet apparatus. The effect of both extracts of <em>Tragia cannabina</em> was studied on carrageenan induced paw edema. The methanolic extract decreased the edema induced in hind paw. The percentage inhibition of paw edema was maximum with methanolic and chloroform extracts of <em>Tragia cannabina</em> at 300mg/kg body weight and has showed significant anti-inflammatory activity. It has been concluded that both the methanolic and chloroform extracts of <em>Tragia cannabina</em> showed significant anti-inflammatory activity comparable to that of reference standard Ibuprofen.</p><p>DOI: <a href="http://dx.doi.org/10.3329/icpj.v1i8.10857">http://dx.doi.org/10.3329/icpj.v1i8.10857</a></p> <p>International Current Pharmaceutical Journal 2012, 1(8): 213-216</p><p> </p>
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