In the present research work, biosynthesis of silver nanoparticles and its activity on bacterial pathogens were investigated. Silver nanoparticles were rapidly synthesized using Urospora sp. and the formation of nanoparticles was observed within 30 min. The results recorded from UV-vis spectrum, Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD) and High Resolution Transmission Electron Microscopy (HRTEM) support the biosynthesis and characterization of silver nanoparticles. From HRTEM analysis, the size of the silver nanoparticles was measured 20 to 30 nm. Further, the antibacterial activity of synthesized silver nanoparticles showed effective inhibitory activity against the pathogens namely: Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.
The present research aimed to screen and evaluate the anticancer effect of Naringi crenulata phytocompounds on HER2þ human breast cancer cells. The cytotoxicity assay was performed to select effective solvent extraction. Extracted compounds showed lower toxicity on normal breast cells and significant cytotoxicity on human HER2þ breast cancer cells (SK-BR3) with an IC 50 value of 24.59 lg/mL. The results indicate that the Naringi crenulata extract (NCE) shows anticancer potential via stimulating the cellular death of cancerous cells. The findings of the present study thus suggest that NCE supplementation might help in the treatment of HER2þ breast cancer.
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