NGF plus DHA treatment after PRK in rabbits is associated with increased corneal nerve surface area, increased epithelial proliferation, and decreased rose bengal staining compared with NGF, DHA, or vehicle control alone. The combination of NGF plus DHA yields faster nerve recovery after PRK and may have therapeutic usefulness in the treatment of post-PRK dry eye and other neurotrophic keratopathies.
The histological changes that occur after CK may be responsible for the well-established regression of its refractive effect. A better understanding of the wound-healing response after CK is necessary to improve the long-term stability of the procedure.
PURPOSE: To evaluate the long-term refractive results of LASIK for myopia complicated with intraoperative epithelial defects.
METHODS: Twenty-six eyes with epithelial defects on the LASIK flap were compared with the contralateral eye that had no intraoperative complications. Pre- and postoperative data were compared between the two groups including 3-, 6- and 12-month postoperative spherical equivalent refraction, amount of undercorrection, and complications.
RESULTS: Eyes with intraoperative epithelial defects showed more undercorrection at 3 and 6 months postoperatively (P<.05). No statistically significant difference was noted at 12 months. Twenty (76%) eyes in the epithelial defect group lost best spectacle-corrected visual acuity (BSCVA) at 3 months postoperatively compared with 2 (7%) eyes in the control group. By 1 year, however, only 2 (7%) eyes in the epithelial defect group and no eyes in the control group lost >1 line of BSCVA. Diffuse lamellar keratitis was observed in 15 (58%) of 26 eyes with epithelial defects and these eyes had more undercorrections at 6 and 12 months (P<.05) and higher corneal irregularity index at 6 and 12 months compared with controls (P<.05). Eyes with small epithelial defects (>1 mm2 to <3 mm2) had more undercorrections at 6 months (-1.08 ±0.76 diopters [D]) compared with the control group (-0.46±0.87 D). Eyes with centrally located epithelial defects had more undercorrections and increased corneal irregularity index compared with controls (P<.05).
CONCLUSIONS: Intraoperative epithelial defects after LASIK should be considered a severe complication that may result in diffuse lamellar keratitis, induce loss of BSCVA, prolong recovery of visual acuity, and induce undercorrection. [J Refract Surg. 2006;22:54-60.]
This study is conducted to discover the relationship between the growth ta xanh coconut fruit and lipid accumulation in its endosperm. During the fruit development period, several criteria are determined, such as the fresh and dry weight of the crustal or seed, the amount of glucose, protein and lipid in the liquid and solid endosperm. The growth period of ta xanh coconut fruit is 12 months and is divided into four stages, lasting from fruit set to harvest. Each stage lasts about three months: (1) young fruit stage, (2) the growth fruit stage, (3) the growth solid endosperm stage (coconut meat), (4) the maturation and ripening stage. In particular, the young fruit period is the slow growth period of the fruit, followed by the second stage that is marked by a rapid growth of fruit in crustal and liquid endosperm (coconut milk). At the end of this stage, the liquid endosperm not only reaches the maximum size and weight but also contains the highest level of glucose and starch. During the third stage (7th - 9th month), the volume and content (glucose and starch) of the liquid endosperm remain stable. In this stage, the solid endosperm is formed from the liquid endosperm. The final stage is that of reducing the volume of the liquid endosperm whereas the embryo and solid endosperm grow significantly. Additionally, maximum lipid accumulation occurred in both liquid and solid endosperm.
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