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Chemical investigation of the aerial parts of Uvaria rufa (Dunal) Blume collected from Vietnam yielded one new lignan glycoside, ufaside (1), along with six known compounds, oxoanolobine (2), ergosta-4,6,8(14),22-tetraen-3-one (3), catechin (4), epicatechin (5), daucosterol (6) and glutin-5-en-3-one (7). Their chemical structures were determined by using NMR, HR-MS spectroscopic analyses and in comparison with the reported data. A cytotoxic analysis of U. rufa herb extracts was performed for the first time using nine human cancer cell lines (MCF-7, MDA-MB-231, LNCaP, MKN7, SW480, KB, LU-1, HepG2 and HL-60) derived from different tumour types. Of these seven constituents, compounds 2 and 3 displayed moderate cytotoxicity against the human lung adenocarcinoma cell line (LU-1) with IC50 values of 9.22 ± 1.02 μg/mL and 10.21 ± 1.16 μg/mL, respectively.

Two new abietane diterpenes, huperphlegmarin A-B (1-2), were isolated from the aerial parts of Huperzia phlegmaria (L.) Rothm. (Lycopodiaceae), in addition to five known compounds including lycoxanthol (3), 21β-hydroxyserrat-14-en-3β-yl acetate (4), 21α-hydroxyserrat-14-en-3β-yl acetate (5), 21α-hydroxyserrat-14-en-3β-ol (6), and fawcettidine (7). Their structures were determined by the combination analyses of spectroscopy, including 1D-, 2D-NMR, HRESIMS, CD and comparison with the reported data in the literature. Huperphlegmarin B (2) presented the rare 1,11-epoxy group in the molecule. Compounds 3, 4, 5 and 6 were performed for AChE inhibitory activity and compound 3 showed the inhibitory activity against AChE with IC of 465.6 μg/mL.

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Background: Today, conservation and development of indigenous knowledge of medicinal plants are the urgent demand of science. Uvaria grandiflora Roxb. ex Hornem which is used by medicinal experience of people of ethnic minorities in Quang Tri Province has shown in vitro cytotoxic activity in our previous screening tests. This article is an ongoing research to determine the chemical ingredients of this species. Materials: The aerial parts of Uvaria grandiflora Roxb. ex Hornem were collected from Quang Tri Province. Method: Fractional extraction was performed by using organic solvents. Volatile components were analysed by gas chromatography – mass spectrometry (GC-MS and indentified by comparison with published mass spectra database Wiley and NIST. Results: Two major components are δ-cadinene (42.94%) and caryophyllene (9.51%). Some ingredients that consist of γ-muurolene, ar-curcumene, calarene, β-vetivenene, β-bisabolene, cadina-1,4-diene and calacorene have never been reported from U.grandiflora collected from Quang Tri province. According to others references, some of these compounds have abundant bioactivities such as antimicrobial, antioxidant, antiinflammatory activities, especially α-humulene and caryophyllene with anticancer activities in vitro. Fractional extraction was performed by using organic solvents. Volatile components were analysed by gas chromatography – mass spectrometry (GC-MS and indentified by comparison with published mass spectra database Wiley and NIST. Conclusion: A total of sixteen volatile compounds were indentified in n-hexane fraction of Uvaria grandiflora Roxb. ex Hornem. Key words: Uvaria grandiflora, δ-cadinene, α-humulene, caryophyllene