IPF-fibroblasts are refractory to BAG3-mediated autophagy. Knock down of BAG3 per se in IPF fibroblasts does not ameliorate BAG3-mediated autophagy. Therapeutic intervention (pirfenidone+5-azacytidine or pirfenidone+cantharidin) sensitizes IPF fibroblasts to BAG3-mediated autophagy. Drug-induced sensitization of BAG3-mediated autophagy in precision cut lung slices of IPF patients alleviates fibroblast proliferation and collagen deposition.
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