Positron emission tomographic imaging of regional cerebral blood flow changes during panic and anticipatory anxiety has permitted the investigation of the functional brain anatomy of anxiety (1, 2). The largest blood flow change found in these studies occurred bilaterally in the vicinity of the pole of the temporal lobe. This was thought to represent emotionally induced neurophysiologic activity in the temporopolar cortex. Recently, Benkelfat et al. (3) used positron emission tomography (PET) to measure blood flow changes during a cholecystokinin-induced panic attack. Their findings were similar to those reported in (1); however, magnetic resonance (MR) imaging
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