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Although cognitive impairment is linked to unemployment, it does not appear to inform disclosure decisions. Early disclosure may help maintain employment if followed by appropriate accommodations.

We have established benchmark scores for popular motor and cognitive tests that are associated with specific degrees of impairment in work status.

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HIV-associated PM deficits are common and exert a significant adverse effect on the daily lives and health of infected persons. Much work remains to be done to understand the cognitive architecture of HIV-associated PM deficits and the most efficient means to enhance PM functioning and improve health outcomes in persons living with HIV.

HIV-associated neurocognitive disorders (HAND) occur in approximately 50% of HIV-infected individuals, yet available diagnostic criteria yield varying prevalence rates. This study examined the frequency, reliability, and sensitivity to everyday functioning problems of three HAND diagnostic criteria (DSM-5, Frascati, Gisslén). Participants included 361 adults with HIV disease and 199 seronegative adults. Neurocognitive status as defined by each of the three diagnostic systems was determined via a comprehensive neuropsychological battery. Everyday functioning was evaluated through self-report and clinician ratings. Results of logistic regressions revealed an association of HIV serostatus with Frascati-defined neurocognitive impairment (p=.027, OR=1.7[1.1, 2.7]), but not DSM-5 or Gisslén-defined criteria (ps>.05). Frascati and DSM-5 criteria demonstrated agreement on 71% of observations, Frascati and Gisslén showed agreement on 80%, and DSM-5 and Gisslén criteria showed agreement on 46%, though reliability across the three criteria was poor. Only Frascati-defined neurocognitive impairment significantly predicted everyday functioning problems (p=.002, OR=2.3[1.4,3.8]). However, when both neurocognitive and complaint criteria were considered, the DSM-5 guidelines demonstrated significant relationships to everyday functioning, serostatus and also increased reliability overtime compared to neurocognitive criteria alone (all ps < .05). A subset (n = 118) of the HIV+ group was assessed again after 14.0 (2.2) months. DSM-5 criteria evidenced significantly higher rates of incident neurocognitive disorder compared to both Frascati (p = .003) and Gisslén (p = .021) guidelines, while there were fewer remitting neurocognitive disorder diagnoses when Gisslén criteria were applied to the study sample compared to Frascati (p = .04). Future studies should aim to identify gold standard biological markers (e.g., neuropathology) and clinical outcomes associated with specific diagnostic criteria.

Objective: Over the last 20 years, the internet has become a fundamental means by which many people with neurocognitive disorders manage their activities of daily living (ADL; e.g., shopping) and engage in health behaviors (e.g., appointment scheduling). The aim of this review is to summarize the emerging literature on the neuropsychology of performance-based tasks of internet navigation skills (INS) as measures of everyday functioning. Method: We performed a structured, qualitative review of the extant literature on INS using PRISMA guidelines. Results: Seventeen peer-reviewed studies met inclusion criteria and their results suggest that performance-based tests of INS: 1) discriminate healthy adults from some neuropsychological populations (e.g., HIV, multiple sclerosis, traumatic brain injury); 2) are associated with performance-based tests of everyday functioning capacity, domain-specific declines in manifest everyday functioning, and self-reported internet behavior, but not global manifest functional status; 3) correlate with standard clinical neuropsychological tests, particularly executive functions and episodic memory; 4) may relate to demographic factors, most notably age; and 5) have largely unknown psychometric properties (e.g., reliability). Conclusions: This review provided early support for the construct validity of performancebased tasks of INS as modern measures of everyday functioning in neuropsychological populations. Future work is needed to refine these tasks, establish their psychometrics, and