This study was carried out to evaluate the effects of ethanolic leaf extract of Sida acuta on the prostrate of male Wistar rats. Twenty five rats weighing between 180-220 g were assigned to five groups (control, olive oil control, low dose, medium dose and high dose) with five animals each. Normal control fed only on rat chow, olive oil control group received 0.5ml of olive oil. The experimental groups, low dose, medium dose and high dose received 500mg/kg body weight, 1000mg/kg body weight, 1500mg/kg body weight of the extract orally for 60days respectively. The animals in the control groups and the experimental groups were weighed before and after the administrations of the ethanolic extracts of Sida acuta using sensitive balance. All animals were sacrificed at end of sixty days of administration using chloroform anesthesia. The prostate glands were dissected and sectioned for hematoxylin and eosin (H&E) stains. Morphological result from the study revealed increased final body weight compared to the initial body weight. Histological observations of the prostate showed dose dependent distortion of the normal cytoarchitecture, as the high dose revealed prominent distortion. Hence the study suggests that consumption of Sida acuta at high dose may cause adverse effect on the protrate.
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