Trimethylplatinum(IV) systems with labile ligands and weakly coordinating anions were investigated
with respect to their Lewis-acidity and their ability to act as Lewis-acidic catalysts. The Lewis-acidity of
tetrameric trimethylplatinum(IV) triflate (triflate = trifluoromethanesulfonate, OTf), [{Me3PtOTf}4], toward
carbonyl compounds was quantified by NMR titration with crotonaldehyde (Childs' method) in CD2Cl2.
The data show moderate but significant Lewis-acidity of the trimethyl platinum(IV) center (27% of the
acidity of BBr3) and commensurate (moderate) intrinsic catalytic activity of the trimethylplatinum(IV)
unit. Crystals of an aldehyde adduct were obtained. X-ray crystallography shows a binuclear metal complex,
[{Me3Pt(crotonaldehyde)(μ-OTf)}2]. Despite the relatively low Lewis-acidity, in the absence of oxygen-donor ligands, the trimethylplatinum(IV) is capable of decomposing the [B(ArF)4]- anion (ArF = 3,5-(CF3)2C6H3) to yield B(ArF)3, apparently via aryl abstraction. Salt metathesis reactions of [{Me3PtOTf}4]
with Na[B(ArF)4] in the presence of oxygen-donor ligands lead to mixtures that are highly catalytically
active in the diastereoselective Mukaiyama-aldol reaction, likely via generation of very electrophilic silicon
species.
Background: An individualized food insecurity protocol is defined as a comprehensive process of screening and set of interventions designed around the specific needs of an individual patient including but not limited to such factors as work schedule, place of living, and forms of identification. The aim of this project is to identify whether an individualized food insecurity protocol reduces food insecurity in the patients seen at the East Harlem Health Outreach Partnership (EHHOP), a student-run, attending-directed free clinic in East Harlem.
Methods: Twenty-one patients who had screened positive for food insecurity in the past year were enrolled in the study. Pre- and post-intervention scores based on responses to a modified version of the United States Department of Agriculture’s Six-Item Short Form of the Food Security Survey were recorded, compiled as aggregate data, and compared using the Wilcoxon signed-rank test.
Results: The results of this study demonstrate that an individualized protocol was successful in reducing food insecurity (p = 0.005). However, for certain groups, the protocol was not as effective, including patients with poor continuity of care and unstable living conditions.
Conclusions: These results showed that the individualized protocol was effective for many but not all participants. Patients may have compounding factors that require additional interventions to supplement this protocol. This protocol is low cost to implement and adaptable to other clinical settings.
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