Compared with placebo, there is a higher likelihood of experiencing several amiodarone-related adverse effects with exposure to low daily doses of the drug. Thus, although low dose amiodarone may be well tolerated, it is not free of adverse effects.

Abstract-Radio-frequency (RF) hepatic ablation, offers an alternative method for the treatment of hepatic malignancies. We employed finite-element method (FEM) analysis to determine tissue temperature distribution during RF hepatic ablation. We constructed three-dimensional (3-D) thermal-electrical FEM models consisting of a four-tine RF probe, hepatic tissue, and a large blood vessel (10-mm diameter) located at different locations. We simulated our FEM analyses under temperature-controlled (90 C) 8-min ablation. We also present a preliminary result from a simplified two-dimensional (2-D) FEM model that includes a bifurcated blood vessel. Lesion shapes created by the four-tine RF probe were mushroom-like, and were limited by the blood vessel. When the distance of the blood vessel was 5 mm from the nearest distal electrode 1) in the 3-D model, the maximum tissue temperature (hot spot) appeared next to electrods A. The location of the hot spot was adjacent to another electrode 2) on the opposite side when the blood vessel was 1 mm from electrode A. The temperature distribution in the 2-D model was highly nonuniform due to the presence of the bifurcated blood vessel. Underdosed areas might be present next to the blood vessel from which the tumor can regenerate.

Desmethylastemizole and astemizole cause equipotent block of HERG channels, and these are among the most potent HERG channel antagonists yet studied. Because desmethylastemizole becomes the dominant compound in serum, these findings support the postulate that it becomes the principal cause of long QT syndrome observed in patients following astemizole ingestion. Norastemizole block of HERG channels is weaker; thus, the risk of producing ventricular arrhythmias may be lower. These findings underscore the potential roles of some H1-receptor antagonist metabolites as K+ channel antagonists.

Finite element (FE) analysis has been utilised as a numerical tool to determine the temperature distribution in studies of radio frequency (RF) cardiac ablation. However, none of the previous FE analyses clarified such computational aspects as software requirements, computation time or convergence test. In addition, myocardial properties included in the previous models vary greatly. A process of FE modelling of a system that included blood, myocardium, and an ablation catheter with a thermistor embedded at the tip is described. The bio-heat equation is solved to determine the temperature distribution in myocardium using a commercial software application (ABAQUS). A Cauchy convergence test (epsilon = 0.1 degree C) was performed and it is concluded that the optimal number of elements for the proposed system is 24610. The effects of changes in myocardial properties (+/- 50% electric conductivity, +100%/-50% thermal conductivity, and +100%/-50% specific heat capacity) in both power-controlled (PCRFA) and temperature-controlled RF ablation (TCRFA) were studied. Changes in myocardial properties affect the results of the FE analyses of PCRFA more than those of TCRFA, and the maximum changes in lesion volumes were -58.6% (-50% electric conductivity), -60.7% (+100% thermal conductivity), and +43.2% (-50% specific heat).

We used the finite element method to study the effect of radio-frequency (RF) catheter ablation on tissue heating and lesion formation at different intracardiac sites exposed to different regional blood velocities. We examined the effect of application of RF current in temperature- and power-controlled mode above and beneath the mitral valve annulus where the regional blood velocities are high and low respectively. We found that for temperature-controlled ablation, more power was delivered to maintain the preset tip temperature at sites of high local blood velocity than at sites of low local blood velocity. This induced more tissue heating and larger lesion volumes than ablations at low velocity regions. In contrast, for power-controlled ablation, tissue heating was less at sites of high compared with low local blood velocity for the same RF power setting. This resulted in smaller lesion volumes at sites of low local velocity. Our numerical analyzes showed that during temperature-controlled ablation at 60 degrees C, the lesion volumes at sites above and underneath the mitral valve were comparable when the duration of RF current application was 10 s. When the duration of RF application was extended to 60 s and 120 s, lesion volumes were 33.3% and 49.4% larger above the mitral valve than underneath the mitral valve. Also, with temperature-controlled ablation, tip temperature settings of 70 degrees C or greater were associated with a risk of tissue overheating during long ablations at high local blood velocity sites. In power-controlled ablation (20 W), the lesion volume formed underneath the mitral valve was 165.7% larger than the lesion volume above the mitral valve after 10 s of ablation. We summarized the guidelines for energy application at low and high flow regions.