Patients with CAD on dual antiplatelet therapy who used nebivolol had significantly lower levels of residual ADP-induced platelet aggregation compared to baseline than patients who used bisoprolol.

Disorders and morphological abnormalities affecting the adrenal gland, could lead to profound clinical consequences, owing to its biochemical structure-activity and morphological characteristics. The recent focus on theranostic approach has led to a need for tumors characterization and early diagnosis at the molecular level. Many radiotracers have been developed with specific imaging characteristics for the adrenal tumors, by exploiting different physiological mechanisms of uptake and metabolism. The aim of present study is to provide a prospective confirmation of 131I-MIBG and 99mTc-HYNIC-TOC scintigraphy, for the evaluation of patients with known or suspected tumors of the adrenal region. The research is designed as a cross-sectional observational study of the clinical correlates and diagnostic accuracy of radionuclide-based imaging methods in relation to in vitro analysis, clinical manifestations and morphological characteristics of these tumors. Furthermore, the present study also evaluates the usefulness and the clinical impact of each radiopharmaceutical for the detection and management of tumors, and functional imaging modality as well. Visual scintigraphic appearance of an increased focal tracer uptake in the suspected tumor site revealed that 99mTc-HYNIC-TOC is highly sensitive and reliable tumor-seeking radiotracer for adrenal tumors, but does not distinguish between adenoma and pheochromocytoma, and the existence of hormone secreting adrenocortical tumor cells. However, 131IMIBG scintigraphy is highly sensitive and specific method only in differentiating catecholamine-secreting adrenal tumors. Clinical significance of this research is in the accurate localization of adrenal tumors, and is of paramount importance for an algorithmic diagnostic approach and management, and provide the rationale to different therapeutic possibilities.

Introduction Onychomycosis is a fungal infection of one or more nails. Causes of onychomycosis are dermatophytes, yeasts and non-dermatophyte molds, but the most common cause is Trichophytonrubrum (T. rubrum) from the group of dermatophyte fungi.. The aims Using sampling determination of the most common clinical type of onychomycosis, lokalization and involvement of the nail plate, and monitoring the effi cacy of methods/tests in the diagnosis of nail onychomycosis. Material and methods This paper is a part of academic IV phase study. The study included 30 patients with onychomycosis. Each sample was seeded on Sabouraud Dextrose Agar (SDA) and Diluted SDA (D-SDA) at 28°C and 37°C, as well as the Dermatophyte Test Medium (DTM) at 28°C. Identifi cation of isolated fungi to the level of genus/species has been based on macroscopic and microscopic characteristics by KOH and Blancophor fl uorescent dye. PCR were performed to detect T. rubrum-specifi c and pan-dermatophyte multiplex PCR product. Informed consent was obtained from all patients. Results The most common clinical form was subungual lateral distal onychomycosis (DLSO)of the hands and feet pollex fi ngernails, while the size of the involvement of the nail plate was 1/2-1/3 in the majority of patients. Cultivation gave a positive result in 50% of cases and the most commonly isolated microorganism was the T. rubrum.For negative cultures (50%) the PCR was carried out which demonstratedhigh sensitivity and T. rubrum remained the most frequently detected. Conclusions Using the methods of cultivation and PCR, onychomycosis was confi rmed in 28 (93.3%) patients. Cultivation gave a negative result in 50% of cases, while the PCR was positive in 86.6%. Our research shows the highest incidence of T. rubrum (60%). In continuation of this study will be analyzed the choice and eff ectiveness of therapy.

IntroductionInternet use (IU) commonly refers to sedentary lifestyle and may be addictive, especially among children. The aim of this study was to investigate the relationship between IU and some aspects of child physical and psychosocial development.MethodologyWe conducted a cross-sectional survey by using a screen-time based sedentary behavior questionnaire and Strengths and Difficulties Questionnaire (SDQ)—among 836 primary school children in the Braničevo District. The children’s medical records were analysed for vision problems and spinal deformities. Their body weight (BW) and height (BH) were measured and body mass index (BMI) was calculated as BW in kilograms divided by BH in meters squared (kg/m2).ResultsThe average age of respondents was 13.4 (SD 1.2) years. The mean duration of daily Internet use and sedentary behavior was 236 (SD 156) and 422 (SD 184) minutes, respectively. There was no significant correlation between daily IU and vision problems (near sightedness, farsightedness, astigmatism, strabismus), and spinal deformities. However, daily Internet use is significantly associated with obesity (p < 0.001) and sedentary behavior (p = 0.01). There was significant correlation between emotional symptoms with total Internet usage time, and total sedentary score (p < 0.001 for both, r = 0.141 and r = 0.132, respectively). There was a positive correlation between the total sedentary score of children and hyperactivity/inattention (r = 0.167, p < 0.001), emotional symptoms (r = 0.132, p < 0.001), and conduct problems (r = 0.084, p < 0.01).ConclusionIn our study, children’s Internet use was associated with obesity, psychological disturbances and social maladjustment.

Context.The variety of tumor-seeking radiopharmaceuticals, which are currently in clinical use, may have a potential role as imaging agents for adrenal gland tumors, due to physiological characteristics of this organ.Objective. The purpose of this study was to evaluate the diagnostic potential of 99m Tc-HYNIC-TOC, 99m Tc(V)-DMSA, and 99m Tc-MIBI in the assessment of adrenal tumors, by correlating with imaging findings and histopathologic results.Design. The research is designed as a crosssectional prospective study.Patients and method. The study included 50 patients with adrenal tumors (19 hormone-secreting and 31 nonfunctioning) and 23 controls without adrenal involvement. In all patients, single-photon emission computed tomography (SPECT) was performed, using qualitative and semiquantitative analysis. The tumor to nontumor tracer uptake was conducted by using a region-ofinterest technique. Adrenal to background (A/B) ratio was calculated in all cases.Results. 99m Tc-HYNIC-TOC scintigraphy showed a high statistical significance between A/B ratios, while other two tracers resulted in a lower sensitivity, specificity and accuracy. Futhermore, 99m Tc-HYNIC-TOC could have a high diagnostic yield to detect adrenal tumors (the receiveroperating-characteristic curve analysis, A/B ratio cut-off value of 8.40). Conclusion.A semiquantitative SPECT analysis showed that 99m Tc-HYNIC-TOC is a highly sensitive tumorseeking agent for the accurate localization of adrenal tumors.

BackgroundThe aim of this study was to evaluate the behavioral uptake and ability to diagnose pituitary adenoma (PA) using tumor-seeking radiopharmaceuticals, and to provide a semiquantitative analysis of tracer uptake in the pituitary region.Patients and methodsThe study included 33 (13 hormonally active and 20 nonfunctioning) patients with PA and 45 control participants without pituitary involvement. All patients (n=78) underwent single photon emission computed tomography (SPECT) imaging with technetium-99m-labeled hydrazinonicotinyl-tyr3-octreotide (99mTc-HYNIC-TOC), dimercaptosuccinic acid (99mTc(V)-DMSA) and hexakis-2-methoxyisobutylisonitrile (99mTc-MIBI). A semiquantitative analysis of abnormal uptake was carried out by drawing identical regions of interest over the pituitary area and the normal brain on one transverse section that shows the lesion most clearly. The pituitary uptake to normal brain uptake (P/B) ratio was calculated in all cases.ResultsThe result of this study confirms that the SPECT semiquantitative method, with all three tracers, showed statistically significant differences between the PA group and the controls. However, 99mTc-HYNIC-TOC scintigraphy could have the highest diagnostic yield because of the smallest overlap between the P/B ratios between adenoma versus nonadenoma participants (the receiver operating characteristic curve P/B ratio cut-off value was 13.08). In addition, only 99mTc-MIBI SPECT have the diagnostic potential to detect secreting PAs, with statistically significant differences between groups (P<0.001), with an receiver operating characteristic curve P/B ratio cut-off value of 16.72.ConclusionA semiquantitative analysis of increased focal tracer uptake in the sellar area showed that 99mTc-HYNIC-TOC is a highly sensitive and reliable tumor-seeking agent for detecting PA, whereas 99mTc-MIBI SPECT is a highly sensitive and specific method in differentiating hormone-secreting pituitary tumor.

Objectives: Our goal was to conduct the first survey and screening of colon cancer incidence trends in the Macva district, Serbia. Methods: Age-specific incidence of colon cancer among the > 20 years old adults that were diagnosed from 2006-2015 was analyzed using data from Cancer Registries of the Sabac Public Health Institute and Public Health Institute of Serbia. Linear model of the incidence rates and annual change in age-standardized incidence rates, by sex and age were presented. Standardized incidence ratio, based on average age-specific incidence rates of colon cancer for Sabac municipality and Central Serbia was calculated. Results: Based on the results from our study, colon cancer incidence in Sabac municipality increased in males and females in the last ten years. Risk of developing colon cancer in males and females, calculated by standardized rates ratios was 1.5 and 1.3, respectively. Linear, rising trend for age-standardized incidence rates in the population of Sabac compared to other municipalities in the Macva district was recorded. Furthermore, standardized incidence ratios for both females and males were higher compared to data from Central Serbia (28% and 22%, respectively). Conclusion: Our study revealed increased colon cancer incidence, with a linear increase of colon cancers in young males and also in > 50 years old population.

Being overweight is one of the leading health problems of the 21st century. In different parts of Europe, different overweight statuses are noted. The aim of this study was to explore the correlation between the socioeconomic environment and the level of nutrition in the Serbian population. This research is part of the fourth national survey of the health of the population of Serbia. It was conducted as a descriptive, cross-sectional study. For the purposes of this research, the adult population over the age of 20 was included, and 12,439 respondents were analyzed. The nutritional status was assessed by the body mass index value—BMI. In order to investigate the differences between groups, the chi-squared test was used. The risk of being overweight was evaluated by calculating the odds ratio value, using univariate and multivariate regression. The prevalence of obesity was higher in females than in males, but pre-obesity was more common among male respondents. Males in the age category 55–64 years old, married, employed, with a higher level of education and material status were more likely to be overweight. As for the females, being overweight was most common among unemployed and economically inactive respondents, widowed/divorced, aged 65–74, with a primary school educational level and low material status. The level of nutrition is significantly associated with the socioeconomic environment.