Ca2؉ -regulated exocytosis of lysosomes has been recognized recently as a ubiquitous process, important for the repair of plasma membrane wounds. Lysosomal exocytosis is regulated by synaptotagmin VII, a member of the synaptotagmin family of Ca 2؉ -binding proteins localized on lysosomes. Here we show that Ca 2؉ -dependent interaction of the synaptotagmin VII C 2 A domain with SNAP-23 is facilitated by syntaxin 4. Specific interactions also occurred in cell lysates between the plasma

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