"It takes a membrane to make sense out of disorder in biology. You have to be able to catch energy and hold it, storing precisely the needed amount and releasing it in measured shares". So wrote Lewis Thomas in The Lives of Cells. Domains and rafts are shown in the present Review to play an important role in this amazing behavior of lipid membranes. Topics touched upon include the experimental detection of domains, their composition, domain induction, properties of rafts (a special form of domain), and the relationship of rafts to human diseases. Lipids, polymers, and proteins can contribute to this type of micro- and nanostructuring within membranes, thus imposing a new structural hierarchy on top of the classical bilayer membrane. The purpose of this Review is to develop an appreciation for the multiple organizational levels in self-assembling systems.
[structure: see text] Synthesis, structure, and reactivity toward amines of the new sulfamoylating reagent 2 are described. Compound 2 allowed sulfamoylation of amines under very mild conditions to give sulfamide derivatives in good yields.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.