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The concentrations of Cu, Co, Zn, Ni, V, and Cr in topsoils at six sites located along the lower slopes of Mt. Cameroon were assessed for their potential toxicity to humans and the ecosystem. Soils were collected from horizons down to a depth of 70 cm and analysed for trace element concentration by ICP-MS technique. The Dutch soil quality standards which use %clay/silt and organic matter content to derive target values were used to assess the contamination levels of the soils. The content of these soils was also compared to the United Kingdom ICRCL “soil trigger” values. Zinc and Cu values were persistently below the normal value (A) and occurred in the lower elevation, the region of extreme weathering, while Cr and V values were above the intervention (C) values. The high content of Cr in common fertilisers poses a potential risk in toxicity in the higher elevations experiencing lower weathering rates, where soil Cr levels are elevated.