The anti-microbial action of benzimidazole of
ampicillin, was examined in Vitro beneath a specific conditions,
utilizing the disc diffusion method, against different
gram-positive and gram-negative pathogenic microorganisms
such as Bacillus cereus, Staphylococcus aureus Pseudomonas
aeruginosa and Escherichia Coli. An arrangement of these
compounds were arranged and have appeared to hinder
phthogenic development, the range of the zone of restraint. The
zone of Obstacles of compounds founds from 7 mm2
to 46 mm2
Among the synthesized compounds in common.
6-Methoxy-N-phenyl- 1H-benzo [d]imidazol-2-amine(1c, zone of
inhibition 9 mm2
at 40 µg/ml against Escherichia coli ) and
6-Chloro-N-phenyl-1H-benzo [d]imidazol-2-amine (1d, zone of
inhibition 18 mm2
at 40 µg/ml against Bacillus cereus) have
appeared great movement. While 1j, zone of inhibition 20 mm2
at
40 µg/ml), and (1i, zone of inhibition 20 mm2
at 40 µg/ml) were
found to be displayed directly to great action against Bacillus
cereus and Escherichia coli. 1p did not appear any movement
against Staphylococcus aureus .1e did not appear any movement
against Escherichia Coli and Staphylococcus
aureus.The results have shown clearly that the contribution of el
ectron -donation and electron- withdrawal to the aromatic ring i
ncreases antibacterial activity. Target benzimidazolessamples sho
wed antibacterial & reference antibiotic ampicillin in vitro.
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