An efficient gold-catalyzed synthesis of substituted 3-methylene-3,4-dihydrobenzo[b]oxepinones from ortho-O-propargyl substituted aryl enaminones has been achieved. In this transformation a new C-C bond formation occurred regioselectively via 7-exo-dig cyclization. Benzooxepinone derivatives were obtained in good to excellent yields in a one-pot synthesis at ambient temperature.
An efficient gold-catalyzed formation
of 6-hydroxyindoles from
substituted alkynylcyclohexadienones and amines have been developed.
In this reaction two new C–N bonds were formed, and moderate
to very good yields of the 6-hydroxyindole derivatives were obtained
in one pot. This organic transformation tolerates a range of substituted
alkynylcyclohexadienones and amines, which resulted in 6-hydroxyindole
derivatives selectively.
An efficient gold-catalyzed synthetic protocol for the construction of 1,2-dihydro[c][2,7]naphthyridines from 2-aminophenyl prop-2-yn-1-yl enaminones has been developed. In this organic transformation new C-C and C-N bond formations occur via 6-endo-dig cyclization and condensation. 1,2-Dihydro[c][2,7]naphthyridine derivatives were obtained in good to excellent yields in a one-pot synthesis at ambient temperature.
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