The ability of sodium p‐benzyl‐4‐[1‐oxo‐2‐(4‐chlorobenzyl)‐3‐phenylpropyl]phenyl phosphonate (N‐0164) to antagonize contractions produced by prostaglandins E2 and F2α on isolated preparations of gerbil, rat and guinea‐pig gastrointestinal muscle has been studied.
N‐0164 was found to be a potent, partially selective prostaglandin antagonist in these isolated smooth muscle preparations. The blockade produced by N‐0164 in the isolated stomach strip of the rat had some, but not all, the characteristics of a competitive antagonism.
N‐0164 produced a dose‐dependent decrease in tone in the rat stomach strip that was abolished by pretreatment of the preparation with indomethacin.
N‐0164 prevented diarrhoea induced by prostaglandin E2 in mice when given by intraperitoneal injection but was less effective when given orally.
N‐0164 inhibited oedema induced with croton‐oil and pyridine‐ether in the mouse ear.
N‐0164 delayed the onset of erythema following ultraviolet irradiation of guinea‐pig skin only when an equimolar amount of pralidoxime chloride was added to the vehicle.
It is concluded that N‐0164 is a potent, partially selective prostaglandin antagonist on several isolated smooth muscle preparations. N‐0164 exhibits activity in vivo particularly following local application when problems associated with penetration and distribution are minimized.
CARDIOVIT is one of the first and largest studies in India to provide insight into the prevalence of hypertHcy, its association with AVD and conventional risk factors and the role of multivitamins in reducing it.
Rapid advances in the treatment of breast cancer, especially in the form of hormone therapy have truly increased the hope of longer and better disease-free survival for these patients. Exemestane, a third generation aromatase inhibitor has been extensively evaluated in metastatic as well as adjuvant therapy of breast cancer. It has also been evaluated for its safety profile, especially on bone and lipids. Exemestane provides hope to the patients with breast cancer both in early and metastatic disease. This review analyzes all the aspects of exemestane therapy.
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