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The selection of suitable solvents is a crucially important subject in a wide range of chemical processes. The study presents a solvent selection guide where 151 solvents were assessed, including a significant number of recently reported bio-based solvents. The assessment procedure involves grouping of solvents according to their physicochemical parameters and ranking within clusters according to their toxicological and hazards parameters. Grouping of solvents resulted in formation of three clusters -nonpolar and volatile (35 solvents), nonpolar and sparingly volatile (35 solvents) and polar ones (81 solvents). The comparison of toxicological and hazard related data indicated that solvents from the third cluster should be preferentially chosen. Within each group, a solvent ranking was performed by means of the TOPSIS procedure based on 15 different criteria. Because of lack of certain data (especially toxicological), different ranking confidence levels were introduced. The highest confidence rankings were performed only for some solvents but with all considered criteria. Low confidence rankings were created for all solvents but were based on certain criteria only. The results of our solvent selection guide (SSG) are generally in agreement with results of others but allow for finer ranking of solvents. The assessment procedure is easy to be adapted to individual chemist's needs and allows to include new solvents to the ranking.

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