Summary. Forty patients participated in a randomized controlled trial of complete bed rest versus ambulation as desired in the management of proteinuric hypertension during pregnancy. Daily increases in serum human placental lactogen and oestriol concentrations were greater in the rested group. An especially‘at risk’ group of 10 patients with both hyperuricaemia and severe fetal growth retardation was identified. Strict confinement to bed in these cases seemed to encourage the development of the premonitory symptoms of eclampsia, but was associated with a better prognosis for the fetus.
Twenty-five patients received 10 ml co-trimoxazole (800 mg sulphamethoxazole and 160 mg trimethoprim) and 25 a placebo by intravenous infusion during one hour from the commencement of surgery for vaginal hysterectomy with anterior colporrhaphy and posterior colpo-perineorrhaphy. Single-dose chemoprophylaxis with co-trimoxazole was shown to be effective in reducing the incidence of postoperative febrile morbidity and urinary tract infection, especially that caused by Proteus species.
Summary
Plasma urea and urate concentrations were determined daily for up to seven days in 40 pregnant women who had been admitted to hospital because of proteinuric hypertension and who were then allocated at random to either complete rest in bed or to being allowed to move freely in the ward. Neither management was superior to the other in improving renal function. The prognostic significance of plasma urea and urate concentrations to maternal and fetal outcome was confirmed.
Plasma urea and urate concentrations were determined daily for up to seven days in 40 pregnant women who had been admitted to hospital because of proteinuric hypertension and who were then allocated at random to either complete rest in bed or to being allowed to move freely in the ward. Neither management was superior to the other in improving renal function. The prognostic significance of plasma urea and urate concentrations to maternal and fetal outcome was confirmed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.