Diffusion is one of the key nature processes which plays an important role in respiration, digestion, and nutrient transport in cells. In this regard, the present article aims to review various diffusion approaches used to fabricate different functional materials based on hydrogels, unique examples of materials that control diffusion. They have found applications in fields such as drug encapsulation and delivery, nutrient delivery in agriculture, developing materials for regenerative medicine, and creating stimuli-responsive materials in soft robotics and microrobotics. In addition, mechanisms of release and drug diffusion kinetics as key tools for material design are discussed.

Herein, a straightforward synthesis approach for the formation of anisotropic microswimmers is proposed as an alternative to a top–down fabrication for asymmetric artificial swimmers. Melamine barbiturate (MBA)–self‐assembled supramolecular crystals are utilized as an asymmetric matrix for selective chemical platinum deposition. Surface functional groups of prevalent crystallographic planes for platinum sorption are presented by acidic sites of the assembly. The formed platinum catalytic layer is separated from the bulk MBA and investigated using X‐Ray photoelectron spectroscopy and scanning electron microscope energy‐dispersive X‐Ray spectroscopy analysis. Both methods confirm platinum adsorption and reduction of platinum ions during the deposition process. The MBA asymmetric swimmers show directional motion in a fuel environment, proved by the mean‐squared displacement study. Previously reported pH‐dependency and encapsulation capacity of MBA opens wide opportunities for functional materials formation.