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Abstract:The synthesis of (R)-1-benzyl-5-(hydroxymethyl)-2-piperidone 1 from key synthon monoacetate (R)-3 has been accomplished conveniently in 6 steps with 93% ee and in 44% overall yield. The key step involved lipase AK desymmetrization of diol 4 to produce monoacetate (R)-3 in 93% ee and 93% yield. Lipase AK desymmetrization of diacetate 5 provided ready access to monoacetate (S)-3 in 93% ee and 54% yield.
who has helped me since the first day I began working in the lab and has helped proofread my thesis despite his busy schedule. Dr. Swapan Kumar Das, former post-doctoral researcher in Prof. Lai's lab, for teaching me procedures for synthesis of CTPP-1 and helping me characterise several other samples using SEM and BET. Mr. Dogancan Karan and Dr. Yap Swee Kun from Prof. Saif's group for teaching me the basic setup of a flow reactor.
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