Background: Historically, oncological management focused on the cure of cancer, regardless of the long-term consequences; the advances in detection and treatment improve the results that impose several considerations on the quality of life and preservation of fertility.Objective: To determine the gonadal damage of patients with breast cancer. Material and method. A prospective and comparative observational study of 14 patients with a history of breast cancer who received chemotherapy (group 1), chemotherapy and radiotherapy (group 2), independently of surgical treatment and 4 patients without cancer, control group (group 3), was performed. Hormone Follicle Hormone was taken, antral follicular count and ovarian volume with color Doppler ultrasound. Results:The 14 patients in different clinical stages of breast cancer, we find that Chemotherapy and Radiotherapy decrease the follicular count, mainly when both are administered; with significant damage between groups 1 and 2; the follicle stimulating hormone levels increased in groups 1 and 2 with respect to the control group, without differences in the tests and the different chemotherapy schemes, all cause ovarian damage and present ovarian dysfunction. Currently there are different techniques to determine the ovarian reserve, the best is the measurement of antimülleriana hormone. Conclusion:It is important to implement individual preventive measures that improve the quality of life including reproduction; due to the risk of ovarian failure due to oncological management, which increases the risk of chronic-degenerative diseases, increasing morbidity and mortality, and the cost of health.
As cervical cancer screening changes from cytology or Pap test to high-risk human papillomavirus (HPV-ar) test, primary worldwide, effective classification tests to decide who of the positive HPV-ar women should receive additional diagnostic evaluation to avoid unnecessary colposcopies and biopsies; with the evaluation of the performance of the dual staining p16 / Ki-67; and partial genotyping, HPV-16/18 for the triage of women with HPV-ar, positive; for the detection of cervical intraepithelial neoplasia grade 3 or more severe (CIN-3 +) and CIN grade 2 or more severe (CIN-2+), diagnosed within 3 years after taking the sample; better risk stratification for CIN-3+ was demonstrated, compared to Pap; in women with positive results they have a higher risk than with Pap, for CIN-3 + (12.0 vs. 10.3%; 11.6%; P = .005); even with better risk stratification for CIN-3+, compared with Pap in women with HPV-ar, positive, regardless of genotype. The greatest balance against CIN-3+ was observed in HPV-16/18 negative women or with dual negative staining, with a low risk to extend the screening intervals. Double staining triage strategies required substantially fewer colposcopies for the detection of CIC-3+ compared to Pap, with a 32.1% reduction in colposcopies compared to the triage strategy currently recommended in the detection of HPV-ar, with the Pap. The results for CIN-2+ are similar. Conclusions; the management of women with HPV-ar test, positive in the detection of cervical cancer; with support from the Pap and dual staining p16 / Ki-67, alone or in combination with HPV- 16/18 genotyping, it provides better risk stratification than strategies based only on the Pap and in countries such as Mexico, where there is organized infrastructure can detect and prevent the cervical cancer.
The G-spot, zone is, a controversial concept in sexual medicine; although, most women report having it; some studies have conflicting results of its existence and nature; It even led to the concept of the clitouretrovaginal complex and its location, size or nature, the evidence is yet to be verified; In the field of female sexuality, it presents a subject still anchored in anecdotes and opinions and explained from non-scientific points, in addition to being overused for commercial and media purposes.
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