This study was designed to evaluate the impact of acupuncture treatment of behavioral changes caused by amphetamines (AMPH).12 female Wistar rats were randomly divided in 3 groups, all treated with 3mg of AMPH by subc. inj. Group I was kept in observation. Group II was submitted to the application of acupuncture needles 15 minutes after AMPH, at the following points: LV13; SP2; SP6; SP9; ST36; UB20 and Ren Mai 12. Group III was submitted to acupuncture needles application in Sham points. Locomotor behavior was assessed using the open field test. Group III submitted to the application of the needles in sham pointsThe animals of group I showed lateral and back movements, jumps, excessive around movements, clonic, tonic and general convulsions, aggressiveness to environment, low position of the posterior and anterior members, pallor of the eyes, ears and feet; total absence of diuresis and defecation; lost of space perception, and abdominal distension. The animals of group II showed respiratory frequency diminishing, recovery from pailure, keeping of active reflex to stimuli. These animals didn't show any convulsion. The application in Sham points does not reproduce the benefits of using the accurate acupuncture points.These results that the animals submitted AMPH administration show locomotor and behavior changes that become reduced by the application of needles in the acupoints
Hyperthyroidism is caused by excess synthesis and secretion of thyroid hormone by the thyroid, which increases the metabolic rate. The experimental model of hyperthyroidism is conducted by an administration of an high dose of levothyroxine for two weeks. The aim of this study is to contribute to the histomorphometric characterization of thyroid follicles' areas on experimental hyperthyroidism.20 Wistar male rats were used, randomly distributed in four groups: control group, kept with no manipulation (Ctrl); group II, which received an administration of 250 mg/kg of levothyroxine by gavage 3 times a week (HT); group III received levothyroxine and acupuncture treatment (HT+AC); group IV, submitted only to the acupuncture treatment. After two weeks, all the animals were sacrificed and fragments from thyroid were collected and analyzed using ImageJ®. The points used for puncture were: ST09, ST36, HC4, RM23.When compared with the control group, we observed more frequently large follicles on group IV than in control group. The animals of group II and III have more often smaller follicles than those observed in control group.The results, although without statistical significance, suggest that acupuncture may have some effect on thyroid function.
Hyperthyroidism can be defined as the consequence of production and excessive action of the thyroid hormones. Acupuncture as been proven effective in the treatment of some pathologies, with minimum side effects.Twenty‐one male Wistar rats were divided into 3 groups: group I – control with no manipulation (Ctrl); group II – received levothyroxine (HT); group III ‐ received levothyroxine and acupuncture (HT+AC). Liver samples were snap frozen in liquid nitrogen and later analyzed by high rotation magic angle NMR spectroscopy (HRMAS) in a in a 14.1 Tesla Varian spectrometer. HRMAS spectral analysis followed by principal component statistical analysis demonstrated that lipids were significantly reduced in the HT group and increased in the HT+AC, the same happening with the aminoacids aspartate and glutamate. Glucose, as well as glycogen were significantly increased in both HT and HT+AC groups.The results suggest that HT reduces hepatic lipid contents, either by increased mobilization or reduced de novo lipogenesis, and that such reduction is reversed by AC treatment. The increase in glucose content is compatible with either an increase in glycogen breakdown or an increase in gluconeogenesis. Our results show an increase in glycogen content in both HT and HT+AC groups thus supporting the later. Accurate evaluation of lipogenesis and glucose turnover is currently underway using the 2H2O method.
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