SUMMARYIn vitro lymphoproliferalive responses lo HIV-I recombinant antigens (gpl60. p34, and Rev protein) were studied in 83 patients with asymptomatic HIV-1 infection (CDC groups il and III) and circulating CD4 lymphocyte numbers > 400/inm\ Significant response to at least one of the three antigens was delected in 524% of ihe subjects, but the responses were weak, and concordance of the response to the three antigens was rare, the frequency of individuals responding to each antigen not e.xceeding 22 4%. Increasing frequencies of response were observed when recall antigens (tetanus toxoid and Cundiita alhican.s glycomannoprotein) (65-5%) and anti-CD3 MoAb {76-6%) were used as stimuli. Although a significant association between lymphocyte response to p24. but not gpl6n. and steadiness of CD4 lymphocyte numbers before the assay was observed, no predictive value for lack of CD4 cell decrease was confirmed for either antigen, and fluctuation ofthe responses to HIV antigens was seen during sub.sequent follow up. The panel of T ceil assays used could be regarded as appropriate for monitoring both HIVspecific responses and T lymphocyte function during immunotherapy with soluble HIV antigens.
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