Background/Aim. Recent data implicate at significance of certain cytokines in the appearance and development of CP, as well as their association with pathohistological and/or clinical characteristics of prostate cancer. The aim of our study was to examine the relationship between the IL-10 concentration with pathohistological and clinical disease characteristics of CP patients. Methods. IL-10 concentration was determined in serum, urine and pms samples of 88 CP patients (initially and after therapy), 20 BPH patients and 15 healthy controls. Results. Comparing to BPH and control groups, CP patients had the highest average sera IL-10 concentration. Interestingly, BPH patients demonstrated the highest concentration in urine and pms samples. Also, patients with G3 gradus and with the highest Gleason score (4+4) demonstrated the highest IL-10 sera level. CP patients without any patohistological sign of tumor invasion had significantly increased serum IL-10, either before or after therapy, comparing to patient group with evident invasion of tumor cells. Therapy induced different IL-10 profile in serum and urine samples. After therapy there was clear significant IL-10 increase in sera of patients of unfavorable Gleason score (4+4), with present infiltration of tumor cells in peritumor tissue (lymphatic, vascular and combined) and in patients with high tumor volumen. Conclusion. CP patients without any pathohistological signs of tumor invasion before therapy have significantly increased serum IL-10 concentration comparing to those with signs of tumor invasion. There is a clear dissociation of IL-10 value between a serum sample and local, urine and pms samples from particular patient. After therapy, high IL-10 sera concentration is present only in patients with high Gleason score, present infiltration of peritumor tissue and high tumor volume.
Background/Aim. Early diagnosis and adequate surgical treatment are the key factors for the course of the laryngeal cancer of the head and neck and the outcome of the surgical treatment in these patients. The aim of the paper is to compare the characteristics of the surgically treated patients with the larynx carcinoma who developed recidivism to those who did not.Material and methods. The study was done as a retrospective observational case-control study on a total of 90 patients with the laryngeal cancer who had been successfully operated on and whose cases had been followed over a period of at least five years after the surgery. After that, they were shorted into two groups based on the development of recidivism, and clinical characteristics of the patients with and without recidive disease were compared.Results. 19 out of 90 patients developed recidivism. Maximum diameter of the tumour was significantly larger in patients without local recidivism. In patients without local recidivism, most common clinical stages were 3 and 4 (32.4%, 40.8%, respectively), whereas in patients with local recidivism stages 1 and 2 were the most common (47.7%, 26.3%, respectively). The average time to disease recurrence in the 19 patients who developed local recidive disease was 648.10 (384.67-911.54) days.Conclusion. Pathohisto-logical analysis showed that samller the size of the tumour and lower T grade at the moment of surgery are precautionary factors for further monitoring of patients with laryngeal cancer.
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