Background: Obesity is associated with metabolic imbalance, including insulin resistance and endothelial dysfunction. Aim: We aimed to evaluate clinical and vascular parameters in obese with or without insulin resistance. Methods: Participants (n¼39) were divided into two groups according to Homeostasis Model Assessment-Insulin Resistance lower (group 1) or higher (group 2) than 2.7. All patients were submitted to clinical, anthropometric, biochemical, vascular structure and endothelial function assessment. Results: The mean age (53+9 vs. 52+7 years, p¼0.784) and body mass index (34.3+4.1 vs. 35.2+3.9 kg/m 2 , p¼0.464) were similar in both groups, and 74.4% were treated hypertensive subjects. Fasting glucose (84+7 vs. 97+18 mg/dl, p¼0.004) and insulin (9.32+2.48 vs. 22.74+7.49 mU/ml, p<0.001) were higher in group 2. Group 2 presented lower HDL-cholesterol (59+14 vs. 42+12 mg/dl, p<0.001) and higher triglycerides (122+87 vs. 191+112 mg/dl, p¼0.042) levels compared with group 1. HOMA-IR was correlated with abdominal circumference (r¼0.51, p¼0.001), abdominal/hip ratio (r¼0.57, p<0.001) and triglycerides/HDL ratio (r¼0.53, p¼0.001). Differences in brachial flow-mediated dilation did not reach statistical significance (10.2+6.2 vs. 7.9+4.7%, p¼0.245). Carotid intima-media thickness, carotid-femoral pulse wave velocity (8.5+1.9 vs. 9.1+1.5 m/s, p¼0.334) and central hemodynamic parameters were also similar between groups. Conclusion: Obese individuals with insulin resistance have higher visceral adiposity associated with impaired glucose and lipid metabolism. Endothelial function and arterial stiffness were similar between the groups, perhaps because of antihypertensive treatment in most of these subjects.
Fundamento: Diversos índices antropométricos têm sido propostos para determinar a associação entre excesso de peso e fatores de risco cardiovascular. Objetivo: Avaliar a relação entre adiposidade corporal e reatividade microvascular em pacientes hipertensos sob terapia anti-hipertensiva. Métodos: Pacientes hipertensos tratados de 40 a 70 anos foram submetidos à avaliação de índices antropométricos: conicidade (IC), adiposidade corporal (IAC), adiposidade visceral (IAV) e relação cintura-estatura (RCE). Os participantes foram divididos pelos tercis de percentual de gordura (%G) obtido pela bioimpedância elétrica (BIA) e submetidos a teste de reatividade microvascular (laser speckle contrast image), medida da velocidade da onda de pulso (VOP). O valor de p < 0,05 foi considerado estatisticamente significativo. Resultados: A variação da área sob a curva (ASC) da perfusão cutânea foi inferior no tercil superior (97 ± 57% vs.
Aims: Pulse wave velocity (PWV) requires the length traveled between two aortic locations and the corresponding transit-time. This study aimed to: 1) design a new wavelet-based approach to estimate transittime and aortic arch (aoPWV W ) from MRI ascending (AA) and descending (AD) aorta flow curves, and 2) compare its performances in terms of associations with: age, tonometric carotid-femoral PWV (cfPWV), and local AA Bramwell-Hill PWV (aaPWV BH ), against the time-domain aortic PWV (aoPWV T ), which is considered as the most relevant MRI approach. Methods: We studied 74 healthy volunteers, (43AE15years) who underwent MRI including: 1) multi-plane cine acquisitions to estimate aortic arch length and AA distensibility, converted into aaPWV BH , and 2) through-plane velocity acquisitions which were automatically segmented to extract AA and AD flow curves, whose systolic-upslope was used to estimate transit-time using crosscorrelation and the newly designed wavelet approach and subsequently to estimate aoPWV T and aoPWV W . First, cross-spectrum of AA and AD flow curves was calculated using wavelets which are more robust to insufficient temporal sampling of systolic-upslope than Fourier. Then the group delay was calculated by averaging the amplitude-weighed phases of systolicupslope. Results: Although strongly related (rZ0.82, slopeZ1.15) associations with age, cfPWV and aaPWV BH were stronger for the wavelet-based approach than aoPWV T (aoPWV W /aoPWV T : rZ0.76/0.63 with age; rZ0.60/0.57 with cfPWV; rZ0.56/0.49 with aaPWV BH , p<0.001). Conclusion: The wavelet-based arch PWV provides stronger associations with age and reference PWV than the previous time-domain estimate. These results suggest that considering supplementary signal information, results in a more reliable estimate of AA to AD transit time.
Aim: Evaluate the possible association between intuitive eating (IE) patterns and metabolic control in patients with type 2 diabetes (T2DM). Methods: Cross-sectionally, outpatients with T2DM attended in University Hospital (Brazil) were submitted to clinical, laboratory, and lifestyle evaluation. IE was assessed by Intuitive Eating Scale-2 (IES-2). Metabolic control evaluated were BMI, HbA1c, LDL and triglycerides targets according to ADA recommendations. Eating patterns were identified by cluster analysis and patients characteristics were compared by appropriate tests. P<0.05 (two-tailed) was considered statistically significant. Study approved Hospital's Ethics Committee (2020-0654). Results: A total of 267 patients were evaluated: 62.2% female, 60 (53-65) years old, BMI=31.9±5.4kg/m², diabetes duration=16±9 years, HbA1c=8.5±1.5%, and median IES-2 total score was 58 (50-67)%. Three IE patterns were identified: Pattern 1=patients with higher intuitive eating; Pattern 2=non emotional-oriented coping; Pattern 3=patients with lower intuitive eating. Pattern 3 patients were younger, included a higher proportion of women, with obesity, psychotropic drugs use, and higher HbA1c values than those in Pattern 1, but not than Pattern 2. Pattern 1 patients presented a lower BMI, fasting plasma glucose and serum triglycerides values as compared to the other groups (P<0.05 for all analyses). Logistic regression models confirmed the association of Pattern 3 with higher obesity prevalence (OR=2.21; 95%CI=1.04-4.70) and triglycerides values out of target (OR=3.32; 95%CI=1.53-7.71) as compared to Pattern 1, after adjusting for confounders. No associations were observed between HbA1c out of target and lower intuitive eating. Conclusion: In this sample of outpatients with T2DM, eating less intuitively was associated with higher obesity prevalence and triglycerides values out of target as compared to eating more intuitively. Disclosure J.Almeida: None. O.G.Koller: None. V.M.Menezes: None. A.Busanello: None. Funding CAPES (001); FIPE/HCPA (2020-0654)
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.