Summary A potential role of dietary lipids in the management of hepatic glycogen storage diseases (GSDs) has been proposed, but no consensus on management guidelines exists. The aim of this study was to describe current experiences with dietary lipid manipulations in hepatic GSD patients. An international study was set up to identify published and unpublished cases describing hepatic GSD patients with a dietary lipid manipulation. A literature search was performed according to the Cochrane Collaboration methodology through PubMed and EMBASE (up to December 2018). All delegates who attended the dietetics session at the IGSD2017, Groningen were invited to share unpublished cases. Due to multiple biases, only data on GSDIII were presented. A total of 28 cases with GSDIII and a dietary lipid manipulation were identified. Main indications were cardiomyopathy and/or myopathy. A high fat diet was the most common dietary lipid manipulation. A decline in creatine kinase concentrations ( n = 19, P < .001) and a decrease in cardiac hypertrophy in paediatric GSDIIIa patients ( n = 7, P < .01) were observed after the introduction with a high fat diet. This study presents an international cohort of GSDIII patients with different dietary lipid manipulations. High fat diet may be beneficial in paediatric GSDIIIa patients with cardiac hypertrophy, but careful long‐term monitoring for potential complications is warranted, such as growth restriction, liver inflammation, and hepatocellular carcinoma development.

Background: Medical hypnotherapy has shown to be an effective treatment in specified conditions such as abdominal pain or headache. Since 2016 the Beatrix children’s hospital, a tertiary care center, offers medical hypnotherapy for a high variety of complex symptom disorders in pediatric patients.Methods: This retrospective COHORT study analyzed the characteristics of pediatric patients treated with medical hypnotherapy in a tertiary care center as well as the effectiveness of the treatment.Results: 214 patients with complex chronic symptoms were treated with medical hypnotherapy. 48% Percent of all patients referred had more than one symptom and 59% of them had had their symptoms for over a year. An overall improvement of symptoms was achieved in 76% of all patients.Conclusions: Medical hypnotherapy seems an effective treatment for patients with multiple chronic and complex symptoms even in a tertiary clinical setting.