Inflammatory bowel disease (IBD) is recognised to be a prothrombotic state and an increased risk of venous thrombosis has been documented with IBD. However, reports of superficial venous thrombosis are less common, and there is a degree of uncertainty in the appropriate management of such patients. We report about a 55-year-old lady who presented with a flare of ulcerative colitis when cyclosporine (started for a previous episode of acute severe ulcerative colitis) was stopped. This flare was associated with the appearance of cord-like structures on the right lateral abdominal wall, which were confirmed to be thrombosed veins consistent with Mondor’s disease. The patient did not have additional predisposing factors and carcinoma breast was excluded.
Introduction:
The global pandemic of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in Wuhan, China, in December 2019, and has since spread worldwide.[1] This study attempts to summarize current evidence regarding major inflammatory markers, severity predictors and its impact on outcome, which provide current clinical experience and treatment guidance for this novel coronavirus.
Methods:
This is a retrospective observational study done at an urban teaching covid-19 designated hospital. Hospital data were analysed with aim of studying inflammatory markers, predictors and outcome. Patients were classified in Mild, Moderate, Severe & Critical categories of COVID cases. Their clinical parameters, laboratory investigations, radiological findings & Outcome measures were studied. Strength of association & correlation of those parameters with severity and in-hospital mortality were studied.
Results:
A total 204 (N) patients were clinically classified into different severity groups, as per MOHFW and qCSI(quick Covid Severity Index) guidelines, as Mild (34), Moderate (56), Severe (39) and Critical (75). The mean(SD) age of the cohort was 55.1+13.2 years; 74.02% were male. Severe COVID-19 illness is seen more in patients more than 50 years of age. COVID-19 patients having IHD develop worse disease with excess early in-hospital mortality. Respiratory rate & Heart Rate on admission are correlated with severe and stormy disease. Among Inflammatory markers, on admission LDH, D-Dimer and CRP are related with severity and excess in-hospital death rate.
Conclusion:
Advanced age, male gender, IHD, Respiratory Rate & Heart Rate on admission were associated with severe covid-19 illness. S. Lactate Dehydrogenase & D-dimer was associated with severe covid-19 illness and early in-hospital death.
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