are Co-senior authors. Abbreviations Used:: ABT 702, 4-Amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2,3-d]pyrimidine; ADA, adenosine deaminase; ADK, adenosine kinase; DPCPX, 8-cyclopentyl-1,3-dipropylxanthine; HA, Human astrocytes; ITU, 5-iodotubercidin; LDH, lactate dehydrogenase; AbstractBrain adenosine concentrations can reach micromolar concentrations in stressful situations such as stroke, neurodegenerative diseases or hypoxic regions of brain tumours. Adenosine can act by receptor-independent mechanism by reversing the reaction catalysed by S-adenosylhomocysteine (SAH) hydrolase, leading to SAH accumulation and inhibition of S-adenosylmethionine (SAM)-dependent methyl-

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