This study was conducted among reproductive age women between 30-50 yrs diagnosed with uterine fibroids to compare the efficacy and safety of Ormeloxifene and Ulipristal in treatment of uterine fibroids. Methodology: Prospective interventional study was conducted from May 2021 to September 2022 among 40 patients diagnosed with uterine fibroids who were randomly divided into two groups, 20 patients in each group, Group 1 were given Ormeloxifene and group 2 were given Ulipristal Results: Mean fibroids size reduced in patients who took Ulipristal than in Ormeloxifene group which was statistically significant. Mean HB CONC increased in Ulipristal group than in Ormeloxifene group which was statistically insignificant. Conclusion:Ulipristal is better as compared to ormeloxifene in reduction of fibroid size. Ulipristal also reduced menstrual blood loss and improved hemoglobin levels when compared to Ormeloxifene.
Introduction: Tumescent anaesthesia is a practice of giving a very dilute form of local anaesthesia drug combined with epinephrine to a tissue till the tissue becomes firm and tense (tumescent). Delivery is a physiological procedure associated with great pain, which is in turn added by the episiotomy procedure. Advantage of using tumescent anaesthesia as a local anaesthetic agent include that it reduces the blood loss by both epinephrine induced vasoconstriction and hydrostatic compression from the tumescent effect. Tumescent lignocaine absorbed slowly from subcutaneous tissue that produces lower & more delayed peek serum levels and also extended analgesic effect after procedure. Aim and Objectives: To compare the effects of tumescent anaesthesia over 2% lignocaine for episiotomy in patients delivering via labour natural in Rajah Muthiah Medical College and Hospital, Chidambaram. To study the effectiveness of tumescent anaesthesia in decreasing blood loss at episiotomy site. To study the effectiveness of tumescent anaesthesia in reducing pain and prolonging the analgesic effect. To study the effectiveness of tumescent anaesthesia aiding in demarcation of layers of episiotomy wound while repairing. Materials and Methods:To the patients who progress for vaginal delivery in stage two of labour before crowning of fetal head 10 ml of 2% lignocaine and 10 ml of tumescent anaesthesia [0.1% lignocaine with adrenaline) to be instilled into the perineal skin at the episiotomy site left mediolateral (By randomised selection of patients). When fetal head crowns episiotomy to be given and baby to be delivered. After removal of the placenta, episiotomy wound will be sutured in layers. Results:The mean Duration of analgesia in Group A was 93.467 ± 17.4529 & group B was 198.100 ± 12.0669 with P value less than 0.05, which was statistically significant. The mean time of suturing episiotomy n group A was 22.19 ± 1.642 and group B was 12.45 ± 1.947 with P value <0.05, which was statistically significant. Conclusion:The inference of the study shows that tumescent anaesthesia (0.1% lignocaine with adrenaline) has certain benefits when used as local anaesthesia for doing and repairing episiotomy when compared to 2% lignocaine in terms of prolonging duration of analgesia, reducing the time taken to suture episiotomy wound by demarcating the tissues which aids in easy suturing.
Permeable concrete is a special concrete which consists of cement, coarse aggregate and water. Due to rapid growth of globalization and urbanization, the construction of concrete roads increasing day by day which leads to decrease in percolation of storm water, surface runoff occurring to the decrease in ground water table. In previous concrete, single sized aggregate is used to maintain the void ratio in the concrete. The cement paste is bonded with aggregate with a void ratio of 20%. In this investigation, concrete of M20 grade with water cement ratio of 0.38 is used. The properties of concrete were increased by using Rice husk ash and Bagasse ash in changed percentages (10%, 20%, 30%) by weight of cement and with the combination of rice husk ash and bagasse ash 10% (5%RA + 5%BA), 20%(10%RA+10%BA), 30%(15%RA+15%BA) are used. The compressive strength of cubes, split tensile of cylinders are casted, tested after 7 days and 28 days. After testing, the optimum percentages of replacement of admixtures are found in the Permeable concrete. Therefore the strength and durability properties of permeable concrete with the addition of bagasse ash and rice husk ash with partial replacement of cement are compared with conventional concrete.
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