Background: Lymphoma is one of the most ten common cancers in the world as well as in Vietnam which has been ever increasing. It was divided into 2 main groups Hodgkin and non – Hodgkin lymphoma in which non-Hodgkin lymphoma appeared more frequency, worse prognosis and different therapy. Objectives: - To describe some common characteristics in patients with non – Hodgkin lymphoma; - To determine the proportion between Hodgkin and non- Hodgkin lymphoma, histopathological classification of classical Hodgkin by modified Rye 1966 and non-Hodgkin lymphoma by Working Formulation (WF) of US national oncology institute 1982. Materials and Method: This cross-sectional study was conducted on 65 patients with Hodgkin and non- Hodgkin lymphoma diagnosed definitely by histopathology at Hue Central Hospital and Hue University Hospital. Results:. The ratio of male/female for the non-Hodgkin lymphoma was 1.14/1, the most frequent range of age was 51-60 accounting for 35%, not common under 40 years. Non - Hodgkin lymphoma appeared at lymph node was the most common (51.7%), at the extranodal site was rather high 48.3%. The non - Hodgkin lymphoma proportion was predominant 92.3% comparing to the Hodgkin lymphoma only 7.7%; The most WF type was WF7 (53.3%), following the WF6 18,3% and WF5 11,7%; The intermediate malignancy grade of non- Hodgkin lymphoma was the highest proportion accouting for 85%, then the low and the high one 8.3% and 6.7% respectively. Conclusion: The histopathological classification and the malignant grade of lymphoma for Hodgkin and non - Hodgkin lymphoma played a practical role for the prognosis and the treatment orientation, also a fundamental one for the modern classification of non - Hodgkin lymphoma nowadays. Key words: lymphoma, Hodgkin lymphoma, non-Hodgkin lymphoma, classication, grade, histopathology, lymph node
Highlights Anorectal melanoma is a rare disease with poor results and prognosis. Patients are misdiagnosed as hemorrhoids, benign polyps, and even rectal cancer. Early-staging diagnosis and surgical treatment are important to improve overall survival.
Background: Extragastrointestinal stromal tumors (EGISTs) are gastrointestinal stromal tumors(GISTs) that located in abdomen but outside the gastrointestinal tract. EGISTs is not common as GISTs with rate of 1-5%. Previously, EGISTs often diagnosed as gastrointestinal smooth muscle tumors, fibrous tumor or schwannomas. After the presence of the c-kit selective therapy administration(specified inhabition of CD117), the same as GIST, the EGIST are well responsed to this therapy, even when the tumors are at late stages such as invasion or metastasis. . Up to now immunohistochemistry has been indispensable for the diagnosis of EGIST in addition to the standard histopathology. Objectives: To classify the mesenchymal tumors in the abdomen outside the gastrointestinal tract. To study the Histopathological characteristics and Immunohistochemistrical expressing in EGIST. Materials and methods: discriptive research of 14 mesenchymal tumors in the abdomen outside the gastrointestianl tract. Using the inside and outside control for the immunohistochemistrical assessment. Results: 8/14 (57,1%) of these were GISTs, following the leiomyomas and leiomyosarcomas (21,3%). The others are less common including Schwannomas, fibromatosis and lipoma. The EGIST size: 10cm to 35cm, the average 19cm. The fusiform EGISTs accounting for 75%, the other types are less common, encompassing epithelioid and mixed tumors. Risk of Aggressive Behavior in EGIST: the high risk encompassing 100%. The positive proportion of the immunochemistrical markers: CD117 (100%), CD34 (62,5%), SMA (25%), S100 (12,5%). Desmin and CK negative in all cases.
Background: The cytology and the support of clinical symptoms, biochemistry for diagnosis of the cases of effusions are very important. Objectives: - To describe some of clinical symptoms and biochemistry of effusions. - To compare the results between cytology and biochemistry by the causes of pleural, peritoneal fluids. Material & Method: A cross-sectional study to describe all of 47 patients with pleural, peritoneal effusions examinated by cytology in the Hospital of Hue University of Medicine and Pharmacy from April 2013 to January 2014. Results: In 47 cases with effusions, pleural effusion accounting for 55.32%, following peritoneal effusions 29.79% and 14.89% with both of them. The most common symptoms in patients with pleural effusions were diminished or absent tactile fremitus, dull percussion, diminished or absent breath sounds (100%), in patients with peritoneal effusions was ascites (95.24%). 100% cases with pleural effusions, 50% cases with peritoneal effusions and 80% cases with pleural and peritoneal effusions were exudates. The percentage of malignant cells in patients with pleural effusions was 26.92%, in peritoneal effusions was 28.57%, in pleural and peritoneal effusions was 42.86%. The percentage of detecting the malignant cells in patients with suspected cancer in the first test was 57.14%, in the second was 9.53% and 33.33% undetectable. Most of cases which had malignant cells and inflammatory were exudates, all of the cases which had a few cells were transudates. Besides, 7.5% cases which had high neutrophil leukocytes were transudates. Conclusion: Cytology should be carry out adding to the clinical examinations and biochemistry tests to have an exact diagnosis, especially for the malignant ones. For the case with suspected cancer, we should repeat cytology test one more time to increase the ability to detect malignant cells. Key words: Effusion, pleural effusion, peritoneal effusion, cytology, biochemistry
Background: PSA density by the ratio of tPSA/prostatic volume plays a meaningful role for the orientation of diagnosis and the screening of the prostatic diseases, especially for the prostatic carcinoma and benign nodular hyperplasia. Objectives: - To describe some characteristics of the age, ultrasound of the patient with the prostatic carcinoma and benign nodular hyperplasia; - To determine the relation between PSA density and the histopathology of the patient with the prostatic carcinoma and benign nodular hyperplasia. Materials and Method: cross-sectional study on 70 patients including 35 cases with benign nodular prostatic hyperplasia and 35 ones with carcinoma of the prostate. Results: The average age was the same between 2 groups of the diseases, 73 for prostatic carcinoma and 75 for benign nodular hyperplasia. 100% of the lesions was discovered by ultrasound, the average weight of the carcinoma and benign nodular hyperplasia was 57.3g and 46.9g respectively. The tPSA density was higher in carcinoma than in benign nodular hyperplasia (1.22 vs 0.10); With the tPSA density threshold >0.15, the prostatic carcinoma accounting for 78.4%, then the benign group only 21.6%; the Sensitivity and the Specificity were 82.9% and 77.1% respectively. Conclusions: PSA density should be applied for the diagnosis and the screening of the prostatic tumors beside the tPSA test. Key words: tPSA (total PSA), PSA density, ultrasound, prostatic carcinoma, benign nodular prostatic hyperplasia.
Background: Bladder cancer is one of the most frequent type of urinary cancer which has been ever increasing. For the better treatment, the early discovery and definite diagnosis of this disease played an important role. Objective: To describe some clinical symptoms and ultrasound features of tumorlike lesions of the bladder. To diagnose and classify the histopathology of tumorlike lesions of the bladder. Materials, method: cross - sectional study on 64 cases in Hue University Hospital and Hue central hospital from April, 2016 to February, 2017. Results: Hematuria was the most common reason that patients went to hospital (79.7%). Lower abdominal pain and irritation during urination accounting for 9.4% and 6.2% respectively. Only 3 patients with bladder cancer were accidentally discovered through periodic health examination (4.7%). The characteristics of hematuria in bladder tumor was flesh red urine (62.5%) and total hematuria (60.7%). With ultrasonography, the results of 64 patients were divided in 3 groups as follow: bladder tumor, which was the highest rate 87.5%, bladder polyp was 3.1% and focal bladder wall thickening was 9.4%. Of which, the vast majority of these ultrasound images was tumor - like lesions protruding in the lumen of the bladder (75%), the rest was wall thickening lesions (25%). Tumors were different in size, the biggest tumor was 7cm in diameter and the smallest was 0.6cm. Those with the diameter 3cm or bigger accounting for 42.2%, the smaller was 57.8%. Most cases have only one lesion (62.5%) and at lateral wall (46.6%). Histopathologically, cancer was 59/64 case (92.2%): urothelial carcinoma was 98.3 %, squamous cell carcinomawas 1.7% and 5 cases (7.8%) were benign. Most cancerous cases were poorly differentiated, grade II (50.9%) and grade III (32.2%). The stage T1NxMx was 20.3% and worse than T2MxNx was 79.7%. Conclusion: hematuria was the most popular symptom, suggesting bladder cancer. Clinical diagnosing bladder cancer was not high sensitive (61.01%). Ultrasound could detect bladder tumor with high sensitive (89.8%). These patients also needed histopathology classification to diagnose and finally choose the best method for the appropriate treatment. Key words: bladder cancer, histopathology, ultrasound, uroepithelial carcinoma, hematuria
Background: Gastrointestinal Stromal Tumor (GIST) is the most frequent one among the digestive mesenchymal tumors. GIST usually locates under the mucosa of the stomach, esophagus, small intestine, colorectal intestine and evenly sometimes at the mesentery, omentum. Microscopically, GIST appeares as various features. In order to determine the origin of the tumor cell, surgical pathology especially the immunohistochemistry play a key role for the best choice of treatment with the targeted therapy. Objectives: - To study some of the common characteristics of the surgical pathology and immunohistochemistry of GIST. – To apply the GIST Risk Stratification of AFIP 2006 and determine the relation with some of the traditional risk factors. Materials and Method: cross-sectional study of 39 patients diagnosed with GIST at Hue Central Hospital from 6/2011 to 7/2015. Results: the average age 55.87±11.91, the most frequent age 41-60 in both men and women. The tumor size >2-5cm was the most rate 64.1%, GIST mostly located at the stomach, accounting for 48.7%. The spindle cell GISTs were the highest type 87.2%. Immunohistochemistry shown that the positive of CD117, Vimentine, CD34 were 100%, 94.7% and 61.5% respectively. All GISTs were negative for Desmine. The high risk GISTs were the most frequent accounting for 46.2%, following the moderate ones 28.2%, then the low 20.5%, the very low only 5.1%. This study also shown that, there were the relation between the tumor risk level with the tumor necrosis and the mucosa invasion. Conclusion: The application of the Immunohistochemistry with the marker CD117 and the GIST Risk Stratification need carry out for the digestive mesenchymal tumors to choose the best treatment for the patients. Key words: gastrointestinal stromal tumor (GIST), mesenchymal tumor, histopathology, immunohistochemistry
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.