In a study on 147 deceased donor renal transplantation recipients with a mean age of 43.1 years, we found, long-term outcomes of deceased donor renal transplantation in patients with end-stage renal disease were satisfactory and suggested the use of deceased donor renal transplantation as a replacement option for living donors.
INTRODUCTION Diabetes mellitus is one of the most prevalent metabolic diseases which is characterised by elevated blood sugar levels. Type 2 diabetes mellitus constitutes about 90 percent of this group. Untreated DM leads to many complications which are traditionally classified as acute and chronic. The microvascular complications include retinopathy, nephropathy and peripheral neuropathy. Diabetic nephropathy is the most common cause for dialysis and end-stage renal failure across the world. Diabetic nephropathy usually starts with microalbuminuria (UAE 30-300 mg/dL) followed by macroalbuminuria (UAE > 300 mg/dL) and eventually there is progressive loss of renal function by tissue scarring leading on to end-stage renal disease. However, in type 2 DM, there can be a group of patients who can have impaired renal function without albuminuria (UAE<30 mg/ day). This is being called as "non-albuminuric renal failure". Reduced GFR in long duration diabetic patients with normal urine albumin excretion have been reported in increasing frequency. There are very few Indian studies which have been done on this group of type 2 diabetic patients. Hence, this study is aimed to evaluate the clinical profile of non-albuminuric renal insufficiency in type 2 diabetes mellitus. AIM To study the clinical profile of non-albuminuric renal insufficiency in type 2 DM. MATERIALS AND METHODS The study population included 97 patients with non-albuminuric (urine microalbumin less than 30 mg/day, renal insufficiency (GFR less than 60 mL/min. as per Cockcroft-Gault formula) and are diabetic (type 2) admitted in the Department of General Medicine and Nephrology. Patients with comorbidities other than diabetes which can cause renal insufficiency were excluded from the study. A detailed history was taken and clinical assessment was done for all patients. All patients underwent a panel of tests which included complete blood count, blood urea nitrogen, serum creatinine, electrolytes (Na, Cl, K, HCO3), LFT, urine routine examination, urine microalbumin, urine culture, USG abdomen, ECG, fundus assessment, calcium, phosphorus, uric acid. GFR was calculated in all the study population with Cockcroft-Gault formula and the study group was divided into different stages of CKD.
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