The purpose of the study is to present the 10-year results of the combined modality treatment with the use of neutron-photon therapy for patients with T2-4N0-2M0 locally advanced breast cancer (LABC). The study involved 246 LABC patients (T2-4N0-2M0). Analysis of long-term results of multimodality treatment of patients with primary LABC has shown that preoperative neutron therapy is the most effective in the presence of multicentric tumors, radioresistance to neoadjuvant chemotherapy and other adverse prognostic factors.
evaluation the number of horses' dynamics in the region, changes in the number of animals of other branches were studied. The only branch that showed a positive trend is poultrythe livestock increased by 63.9 %. The horse breeding branch suffered the greatest losses (94.0 %). In addition to horse breeding, adverse conditions were noted for the development of sheep husbandry and goat husbandry, where the livestock reduction was 92.9 %. Slightly smaller losses, 84.4 and 78.0 %, respectively, were noted for the cattle breeding and pig breeding branches. As of 1.01. 2018, the number of horses in the region was 0.8 thousand heads or 6.03 % of the required. The problem of horse breeding in the region is the lack of pedigree resources: only 4.38 % of the available stock had documented data on the origin, the most represented breeds were Shetland pony (34.3 %), horses of Western European sport breeds (25.7) and Ukrainian ride horse (20.0 %), stallions of trotter and heavy breed breeds for improving horses of local breeding were not identified. In the absence of use of sires of breeds-improvers, the studied population was small, the average measurements of mares were 149.3-150.8-170.2-18.1 cm, geldings 150.8-151.0-171.3-18, 3 cm. The horses had an underdeveloped skeleton (metacarpal index 12.1 ... 12.2), an almost square format (index 99.2 ... 100.5) and a relatively small chest circumference (chest index 113.7 ... .114.0), a small live weight of 402.4 and 409.8 kg. The use of horses was not effective enough, the working time fund was underutilized by 10.62 ... 27.84 %. Reliable indicators of the relationship with the intensity of use for all measurements, especially for height at the withers (0.641 ... .0.683), chest girth (0.314 ... 0.697), were revealed. The highest coefficients were obtained for the indicator of live weight (0.212 ... 0.755). Based on the foregoing, the main way to enhancement working-user horse breeding in the region is to improve horses in the direction of increasing their height at the withers and live weight through the use of stallions-producers of improving breeds.
The study included 138 breast cancer patients, who received the complex treatment and radiotherapy alone with the use of 6.3 MeV fast neutrons generated within U-120 cyclotron. Neutron therapy used for the prevention of local recurrence was shown to be effective in multimodality treatment of patients with locally advanced breast cancer, and in cases with locally advanced tumor recurrences it is often the only treatment to prolong life of breast cancer patients.
Purpose: To study dosimetric characteristics of neutron radiation field, to determine their role in the formation of the total cytogenetic effect in the patient’s body and to assess the cytogenetic dosimetry capabilities in improving the quality of NT. Material and methods: A therapeutic beam with the average neutron energy of ~6.3 MeV was obtained from the V-120 cyclotron. The radiation field of the beam was investigated with the help of two ionization chambers with different sensitivity to neutrons. Chamber with high and low sensitivities were made of polyethylene and graphite, respectively. To exclude the uncertainty associated with the change in beam intensity in time, a dosimeter monitor operating in the integral mode was used. Results: The dependence of the monitor factor on the irradiated area was measured. The distributions of the absorbed dose of neutrons and γ-radiation over the depth of the tissue-equivalent medium were found. The contribution of γ-radiation to the neutron dose was increased from ~10 % at the entry to the medium to ~30 % at a depth of 16 cm. Dose distributions of scattered neutron and γ-radiation in the plane of the end face of the forming device were obtained. The contribution of these radiations to the dose received by the patient’s body was estimated. This contribution was shown to be comparable with that from the therapeutic beam. The analysis of the influence of NT on the estimation of the frequency of chromosome aberrations in the blood of patients was carried out. Conclusion: The frequency of chromosome aberrations in the blood of patients was determined by the whole-body dose, including dose due to scattered radiation. When using equal focal doses, the cytogenetic effect was found to be dependent on the area of the irradiated field and the depth of the tumor in the patient’s body. The differences in the RBE of neutrons and γ-radiation as well as the instability of the therapeutic neutron beam intensity create uncertainties that do not allow for the necessary control over the doses using the cytogenetic dosimetry. Therefore, cytogenetic dosimetry should be combined with an effective instrument dosimetry method. The use of biodosimetry based on the assessment of the frequency of chromosome aberrations is promising for controlling the average whole-body dose, on which the overall radiation response of the body depends.
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