Plasmacytoma is a rare malignant tumour originating from the plasma cells. This may present itself in the bone marrow (myelomatous) as a solitary bone plasmacytoma or in the soft tissues, as an extramedullary plasmacytoma. Solitary bone plasmacytomas in the head and neck region are very uncommon and initial symptoms may be non-specific and vague. However, the risk of progression towards multiple myeloma with these conditions is high, and therefore early diagnosis is essential for positive therapy outcomes.An 81-year-old patient presented with a pedunculated soft tissue mass in the upper left maxilla. This demonstrated symptoms in keeping with a pyogenic granuloma; however, the rapid growth and haemorrhagic nature raised concerns. Histological examination of the maxillary soft tissue mass revealed dense plasma cell infiltrate, consistent with a solitary plasmacytoma. Extensive investigations were performed to exclude multifocal involvement. Treatment involved complete surgical excision and radiotherapy. The patient remained stable and progression free at 6-month review. The objective of this clinical case report is to highlight this unusual oral pathology to avoid incorrect diagnosis.
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