Since the pioneering work of Kochi in the 1970s, iron has attracted great interest for crosscoupling catalysis due to its low cost and toxicity as well as its potential for novel reactivity compared to analogous reactions with precious metals like palladium. Today there are numerous iron-based cross-coupling methodologies available, including challenging alkyl-alkyl and enantioselective methods. Furthermore, cross-couplings with simple ferric salts and additives like NMP and TMEDA (N-methylpyrrolidone and tetramethylethylenediamine) continue to attract interest in pharmaceutical applications. Despite the tremendous advances in iron cross-coupling methodologies, in situ formed and reactive iron species and the underlying mechanisms of catalysis remain poorly understood in many cases, inhibiting mechanism-driven methodology development in this field. This lack of mechanism-driven development has been due, in part, to the challenges of applying traditional characterization methods such as nuclear magnetic resonance (NMR) spectroscopy to iron chemistry due to the multitude of paramagnetic species that can form in situ. The application of a broad array of inorganic spectroscopic methods (e.g., electron paramagnetic resonance, 57 Fe Mössbauer, and magnetic circular dichroism) removes this barrier and has revolutionized our ability to evaluate iron speciation. In conjunction with inorganic syntheses of unstable organoiron intermediates and combined inorganic spectroscopy/gas chromatography studies to evaluate in situ iron reactivity, this approach has dramatically evolved our understanding of in situ iron speciation, reactivity, and mechanisms in iron-catalyzed cross-coupling over the past 5 years. This Account focuses on the key advances made in obtaining mechanistic insight in iron-catalyzed carboncarbon cross-couplings using simple ferric salts, iron-bisphosphines, and iron-N-heterocyclic carbenes (NHCs). Our studies of ferric salt catalysis have resulted in the isolation of an unprecedented iron-methyl cluster, allowing us to identify a novel reaction pathway and solve a decades-old mystery in iron chemistry. NMP has also been identified as a key to accessing more stable intermediates in reactions containing nucleophiles with and without β-hydrogens. In ironbisphosphine chemistry, we have identified several series of transmetalated iron(II)-bisphosphine complexes containing mesityl, phenyl, and alkynyl nucleophile-derived ligands, where mesityl systems were found to be unreliable analogues to phenyls. Finally, in iron-NHC cross-coupling, unique chelation effects were observed in cases where nucleophile-derived ligands contained *

Isolation and reactivity of iron–NHCs observed during catalysis demonstrate ligand effects on nucleophile chelation, suppressing β-hydride elimination within alkyl–alkyl cross-coupling.

The development of active, robust systems for light-driven hydrogen production from aqueous protons based on catalysts and light absorbers composed solely of earth abundant elements remains a challenge in the development of an artificial photosynthetic system for water splitting. Herein, we report the synthesis and characterization of four closely related Fe bis(benzenedithiolate) complexes that exhibit catalytic activity for hydrogen evolution when employed in systems with water-soluble CdSe QDs as photosensitizer and ascorbic acid as a sacrificial electron source under visible light irradiation (520 nm). The complex with the most electron-donating dithiolene ligand exhibits the highest activity, the overall order of activity correlating with the reduction potential of the formally Fe(III) dimeric dianions. Detailed studies of the effect of different capping agents and the extent of surface coverage of these capping agents on the CdSe QD surfaces reveal that they affect system activity and provide insight into the continued development of such systems containing QD light absorbers and molecular catalysts for H2 formation.

We present a combined ab initio theoretical and experimental study of the magnetic circular dichroism (MCD) spectrum of the octahedral UCl complex ion in the UV-Vis spectral region. The ground state is an orbitally non-degenerate doublet E and the MCD is a -term spectrum caused by spin-orbit coupling. Calculations of the electronic spectrum at various levels of theory indicate that differential dynamic electron correlation has a strong influence on the energies of the dipole-allowed transitions and the envelope of the MCD spectrum. The experimentally observed bands are assigned to dipole-allowed ligand-to-metal charge transfer into the 5f shell, and 5f to 6d transitions. Charge transfer excitations into the U 6d shell appear at much higher energies. The MCD-allowed transitions can be assigned via their signs of the -terms: Under O double group symmetry, E → E transitions have negative -terms whereas E → F transitions have positive -terms if the ground state g-factor is negative, as it is the case for UCl.