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Information processing and exchange between brain nuclei are made through spike series sent by individual neurons in highly irregular temporal patterns. Synchronization in cell assemblies, proposed as a network language for internal neural representations, still has little experimental support. We use a novel technique to extract pathway-specific local field potentials (LFPs) in the hippocampus to explore the ongoing temporal structure of a single presynaptic input, the CA3 Schaffer pathway, and its contribution to the spontaneous output of CA1 units in anesthetized rat. We found that Schaffer-specific LFPs are composed of a regular succession of pulse-like excitatory packages initiated by spontaneous clustered firing of CA3 pyramidal cells to which individual units contribute variably. A fraction of these packages readily induce firing of CA1 pyramidal cells and interneurons, the so-called Schaffer-driven spikes, revealing the presynaptic origin in the output code of single CA1 units. The output of 70% of CA1 pyramidal neurons contains up to 10% of such spikes. Our results suggest a hierarchical internal operation of the CA3 region based on sequential oscillatory activation of pyramidal cell assemblies whose activity partly gets in the output code at the next station. We conclude that CA1 output may directly reflect the activity of specific ensembles of CA3 neurons. Thus, the fine temporal structure of pathway-specific LFPs, as an accurate readout of the activity of a presynaptic population, is useful in searching for hidden presynaptic code in irregular spikes series of individual neurons and assemblies.

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We show that firing activity (spiking) can be regularized by noise in a FitzHugh-Nagumo (FHN) neuron model when operating slightly beyond the supercritical Hopf bifurcation (in the "canard" region). We also provide the conditions for imperfect phase locking between interspike intervals and low amplitude quasiharmonic oscillations. For the imperfect phase locking no need exists of an external signal as it follows from the FHN intrinsic dynamics.

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We consider, both analytically and numerically, the evolution of two-dimensional ͑2D͒ nonlinear matterwave pulses in a Bose-Einstein condensate with a disk-shaped trap and repulsive atom-atom interactions. Due to the strong confinement in the axial direction the sound speed of the system is cϭ(1/2 1/4)c 0 , where c 0 is the corresponding value without the trap. From the 3D order-parameter equation of the condensate, we derive a soliton-bearing Kadomtsev-Petriashvili equation with positive dispersion. When the trapping potential is weak in two transverse directions, a low-depth plane dark soliton can propagate in the condensate with a changing profile but preserving its structure down to the boundary of the condensate. We show that high-depth plane dark solitons are unstable to long-wavelength transverse disturbances. The instability appears as a longitudinal modulation of the soliton amplitude decaying into vortices. We also show how a dark lumplike 2D nonlinear excitation can be excited in the system. Furthermore, a dark lump decaying algebraically in two spatial directions can propagate rather stable in the condensate, but disappears near the boundary of the condensate where two vortices are nucleated. The vortices move in opposite directions along the boundary and when meeting merge creating a new lump. Finally, we also provide results for head-on and oblique collisions of two lumps in the system.

To study how the visual areas of the 2 hemispheres interact in processing visual stimuli we have recorded local field potentials in the callosally connected parts of areas 17 and 18 of the ferret during the presentation of 3 kinds of stimuli: 2.5 degrees squares flashed for 50 ms randomly in the visual field (S1), 4 full-field gratings differing in orientation by 45 degrees and identical in the 2 hemifields (S2) and gratings as above but whose orientation and/or direction of motion differed by 90 degrees in the 2 hemifields (S3). The gratings remained stationary for 0.5 s and then moved in 1 of the 2 directions perpendicular to their orientation for 3 s. We compared the responses in baseline conditions with those obtained whereas the contralateral visual areas were inactivated by cooling. Cooling did not affect the responses to S1 but it modified those to S2 and to S3 generally increasing early components of the response while decreasing later components. These findings indicate that interhemispheric processing is restricted to visual stimuli which achieve spatial summation and that it involves complex inhibitory and facilitatory effects, possibly carried out by interhemispheric pathways of different conduction velocity.